สืบค้นงานวิจัย
Ferrous and ferric differentially deteriorate proliferation and differentiation of osteoblast-like UMR-106 cells
Lertsuwan K. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Ferrous and ferric differentially deteriorate proliferation and differentiation of osteoblast-like UMR-106 cells
ผู้แต่ง / หัวหน้าโครงการ (EN): Lertsuwan K.
บทคัดย่อ (EN): The association between iron overload and osteoporosis has been found in many diseases, such as hemochromatosis, β-thalassemia and sickle cell anemia with multiple blood transfusion. One of the contributing factors is iron toxicity to osteoblasts. Some studies showed the negative effects of iron on osteoblasts; however, the effects of two biological available iron species, i.e., ferric and ferrous, on osteoblasts are elusive. Since most intracellular ionized iron is ferric, osteoblasts was hypothesized to be more responsive to ferric iron. Herein, ferric ammonium citrate (FAC) and ferrous ammonium sulfate (FAS) were used as ferric and ferrous donors. Our results showed that both iron species suppressed cell survival and proliferation. Both also induced osteoblast cell death consistent with the higher levels of cleaved caspase 3 and caspase 7 in osteoblasts, indicating that iron induced osteoblast apoptosis. Iron treatments led to the elevated intracellular iron in osteoblasts as determined by atomic absorption spectrophotometry, thereby leading to a decreased expression of genes for cellular iron import and increased expression of genes for cellular iron export. Effects of FAC and FAS on osteoblast differentiation were determined by the activity of alkaline phosphatase (ALP). The lower ALP activity from osteoblast with iron exposure was found. In addition, ferric and ferrous differentially induced osteoblastic and osteoblast-derived osteoclastogenic gene expression alterations in osteoblast. Even though both iron species had similar effects on osteoblast cell survival and differentiation, the overall effects were markedly stronger in FAC-treated groups, suggesting that osteoblasts were more sensitive to ferric than ferrous. © 2018, Springer Nature B.V.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-85049999197&doi=10.1007%2fs10534-018-0130-6&partnerID=40&md5=0eb05d56f4765009f4bda08c6c92ba34
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): UMR-106 cell line
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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Lertsuwan K.. "Ferrous and ferric differentially deteriorate proliferation and differentiation of osteoblast-like UMR-106 cells". ไม่ระบุหน่วยงาน. ม.ป.ป.

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Ferrous and ferric differentially deteriorate proliferation and differentiation of osteoblast-like UMR-106 cells
Lertsuwan K.
มหาวิทยาลัยมหิดล
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