สืบค้นงานวิจัย
Neutralizing antibodies against Plasmodium falciparum associated with successful cure after drug therapy
Goh Y.S. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Neutralizing antibodies against Plasmodium falciparum associated with successful cure after drug therapy
ผู้แต่ง / หัวหน้าโครงการ (EN): Goh Y.S.
บทคัดย่อ (EN): An effective antibody response can assist drug treatment to contribute to better parasite clearance in malaria patients. To examine this, sera were obtained from two groups of adult patients with acute falciparum malaria, prior to drug treatment: patients who (1) have subsequent recrudescent infection, or (2) were cured by Day 28 following treatment. Using a Plasmodium falciparum antigen library, we examined the antibody specificities in these sera. While the antibody repertoire of both sera groups was extremely broad and varied, there was a differential antibody profile between the two groups of sera. The proportion of cured patients with antibodies against EXP1, MSP3, GLURP, RAMA, SEA and EBA181 was higher than the proportion of patients with recrudescent infection. The presence of these antibodies was associated with higher odds of treatment cure. Sera containing all six antibodies impaired the invasion of P. falciparum clinical isolates into erythrocytes. These results suggest that antibodies specific against EXP1, MSP3, GLURP, RAMA, SEA and EBA181 in P. falciparum infections could assist anti-malarial drug treatment and contribute to the resolution of the malarial infection. © 2016 Goh et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-84979207880&doi=10.1371%2fjournal.pone.0159347&partnerID=40&md5=3afb3b898acaffdbc789d3d3ac519677
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Treatment Outcome
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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Goh Y.S.. "Neutralizing antibodies against Plasmodium falciparum associated with successful cure after drug therapy". ไม่ระบุหน่วยงาน. ม.ป.ป.

Goh Y.S.. "Neutralizing antibodies against Plasmodium falciparum associated with successful cure after drug therapy". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



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Neutralizing antibodies against Plasmodium falciparum associated with successful cure after drug therapy
Goh Y.S.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
Combinatorial Genetic Modeling of pfcrt-Mediated Drug Resistance Evolution in Plasmodium falciparum Artemisinin-resistant Plasmodium falciparum malaria Sequence variation in Plasmodium falciparum merozoite surface protein-2 is associated with virulence causing severe and cerebral malaria Prevalence of Plasmodium falciparum molecular markers of antimalarial drug resistance in a residual malaria focus area in Sabah, Malaysia Plasmodium falciparum field isolates from areas of repeated emergence of drug resistant malaria show no evidence of hypermutator phenotype Differential roles of an Anopheline midgut GPI-anchored protein in mediating Plasmodium falciparum and Plasmodium vivax ookinete invasion Evolution of Fseg/Cseg dimorphism in region III of the Plasmodium falciparum eba-175 gene Effects of sevuparin on rosette formation and cytoadherence of Plasmodium falciparum infected erythrocytes Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance Quantifying connectivity between local Plasmodium falciparum malaria parasite populations using identity by descent
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