สืบค้นงานวิจัย
Validation of G6PD point-of-care tests among healthy volunteers in Yangon, Myanmar
Oo N.N. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Validation of G6PD point-of-care tests among healthy volunteers in Yangon, Myanmar
ผู้แต่ง / หัวหน้าโครงการ (EN): Oo N.N.
บทคัดย่อ (EN): Primaquine and other 8-amnoquinoline based anti-malarials can cause haemolysis in subjects with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Correct diagnosis of G6PD status in patients is crucial for safe treatment of both relapsing stages of Plasmodium vivax and transmitting forms of Plasmodium falciparum. Lack of suitable point-of-care tests has hampered a much needed wide use of primaquine for malaria elimination. In this study we have assessed the performances of two qualitative tests, the fluorescent spot test (FST) and the G6PD CareStart test (CST), against the gold standard quantitative spectrophotometric assay in a population of 1000 random adult healthy volunteers living in Yangon, Myanmar. The prevalence of G6PD deficiency in the Bamar, Karen and in the whole sample set was 6.6% (10.1% in males), 9.2% (21.0% in males) and 6.8% (11.1% in males) respectively. The FST and CST showed comparable performances with sensitivity over 95% and specificity over 90%, however for cases with severe G6PD activity the FTS had improved performance. If used with a conservative interpretation of the signal, the CareStart test has the potential to be used in the field and, by allowing a wider use of primaquine, to help malaria elimination. Copyright: © 2016 Oo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-84962781978&doi=10.1371%2fjournal.pone.0152304&partnerID=40&md5=d39df4d93d184582c65e8ac8d037bf12
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Sensitivity and Specificity
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
หากไม่พบเอกสารฉบับเต็ม (Full Text) โปรดติดต่อหน่วยงานเจ้าของข้อมูล

การอ้างอิง

Oo N.N.. "Validation of G6PD point-of-care tests among healthy volunteers in Yangon, Myanmar". ไม่ระบุหน่วยงาน. ม.ป.ป.

Oo N.N.. "Validation of G6PD point-of-care tests among healthy volunteers in Yangon, Myanmar". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



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Validation of G6PD point-of-care tests among healthy volunteers in Yangon, Myanmar
Oo N.N.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
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