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Antibody response to Zika and Dengue virus among the Zika realtime PCR positive cases in Thailand, 2016
Pongsiri Tanthong - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Antibody response to Zika and Dengue virus among the Zika realtime PCR positive cases in Thailand, 2016
ผู้แต่ง / หัวหน้าโครงการ (EN): Pongsiri Tanthong
บทคัดย่อ (EN): After the large outbreak of Zika virus (ZIKV) since the beginning of 2016, many countries were concerned about virus spreading by mosquito bite. As flavivirus genus, clinical symptoms of ZIKV infection are similar to Dengue virus (DENV). Laboratory diagnosis of infected ZIKV patients has been following continuously. To reveal data of IgM and IgG antibody against ZIKV and DENV, 71 plasma or serum (53 cases) were collected from the 53 Zika rRT-PCR positive cases. The detection of IgM and IgG antibody against ZIKV by EUROIMMUN® ELISA kit and anti-dengue IgM/IgG by in-house capture ELISA were performed. The positive percentage of anti-Zika IgM and IgG were 30.2 (16/53 cases) and 100.0 (53/53 cases), respectively. The cross-reactive antibody from anti-dengue IgM and IgG were 9.1% (2/22 cases) and 18.2% (4/22 cases), respectively. Among anti-Zika IgM positive cases, only 4 from 16 have shown that the ratio of anti-Zika IgM and anti-Zika IgG were greater than 1.0. This study demonstrated the response of antibody among ZIKV infected patients in Thailand. Every patient has anti-Zika IgG while some have anti-Zika IgM. Nevertheless, there were cross reaction from anti-dengue IgM and IgG, development of diagnosis must be improved in the future.
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ภาษา (EN): en
เอกสารแนบ (EN): http://nih.dmsc.moph.go.th/research/showimgdetil.php?id=625
เผยแพร่โดย (EN): National Institute of Health, Department of Medical Sciences
คำสำคัญ (EN): ELISA
เจ้าของลิขสิทธิ์ (EN): National Institute of Health, Department of Medical Science
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Antibody response to Zika and Dengue virus among the Zika realtime PCR positive cases in Thailand, 2016
Pongsiri Tanthong
National Institute of Health, Department of Medical Sciences
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