สืบค้นงานวิจัย
Neuroprotective effects of Cassia tora against paraquatinduced neurodegeneration: Relevance for Parkinson’s disease
Ravi S.K. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Neuroprotective effects of Cassia tora against paraquatinduced neurodegeneration: Relevance for Parkinson’s disease
ผู้แต่ง / หัวหน้าโครงการ (EN): Ravi S.K.
บทคัดย่อ (EN): The aim of the present study was to determine whether Cassia tora extracts could reverse the oxidative stress-induced neurodegeneration in a Parkinson’s disease in vitro model. The leaves were treated with ethyl acetate (CtEA) or methanol (CtME). The extracts were first analysed by HPLC for their phenolic content and then tested for their neuroprotective effects in human SK-N-SH neuroblastoma cells. Cells were pre-treated with various concentrations of extracts followed by incubation with paraquat (14 μM). Firstly, pre-treatment of SK-N-SH cells with 100 μg/mL of CtEA or CtME significantly reduced the paraquat-induced production of reactive oxygen species. Furthermore, both CtEA and CtME reduced the paraquat-induced apoptosis. Moreover, there was a significant reduction of paraquatinduced DNA damage in SK-N-SH cells pre-treated with CtEA or CtME. Finally, both extracts significantly inhibited paraquat-dependent lipid peroxidation. Altogether, these in vitro data establish C. tora as a possible anti-Parkinson natural remedy. © 2017 Informa UK Limited, trading as Taylor & Francis Group.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-85024407991&doi=10.1080%2f14786419.2017.1353504&partnerID=40&md5=62e75e2f271fac0551f67517a42ed3d0
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Senna Plant
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
หากไม่พบเอกสารฉบับเต็ม (Full Text) โปรดติดต่อหน่วยงานเจ้าของข้อมูล

การอ้างอิง


TARR Wordcloud:
Neuroprotective effects of Cassia tora against paraquatinduced neurodegeneration: Relevance for Parkinson’s disease
Ravi S.K.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
Larvicidal and histopathological effects of Cassia siamea leaf extract against Culex quinquefasciatus Multiple pharmacological activities of Caesalpinia crista against aluminium-induced neurodegeneration in rats: Relevance for Alzheimer's disease Effects of polymers as a main component of coating formulations on quality and effects of stability of cucumber seeds Effects of low bisphenol A concentration on protein expression profiles in an in vitro model of non-alcoholic fatty liver disease Effects of cytochrome P450 2C19 and paraoxonase 1 polymorphisms on antiplatelet response to clopidogrel therapy in patients with coronary artery disease Parasite diversity of disease-bearing rodents of Southeast Asia: Habitat determinants and effects on sexual size dimorphism and life-traits Predictiveness of disease risk in a global outreach tourist setting in Thailand using meteorological data and vector-borne disease incidences Integrated Disease Management of White Root Disease on Hevea Rubber in Indonesia By using Trichoderma-Based Biofungicide Triko Combi Mitochondrial changes in β0-thalassemia/Hb E disease Structural and Functional Characterization of a NBS-LRR Disease Resistance Gene Associated With Tolerance against Corynespora Cassiicola Causing Leaf Fall Disease in Rubber (Hevea brasiliensis)
คัดลอก URL
กระทู้ของฉัน
ผลการสืบค้นทั้งหมด โพสต์     เรียงลำดับจาก