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High prevalence of equine‐like G3P[8] rotavirus in children and adults with acute gastroenteritis in Thailand
Ratana Tacharoenmuang - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): High prevalence of equine‐like G3P[8] rotavirus in children and adults with acute gastroenteritis in Thailand
ผู้แต่ง / หัวหน้าโครงการ (EN): Ratana Tacharoenmuang
บทคัดย่อ (EN): Group A rotavirus (RVA) is a major cause of acute gastroenteritis in infants and young children worldwide. This study aims to clarify the distribution of G/P types and genetic characteristics of RVAs circulating in Thailand. Between January 2014 and September 2016, 1867 stool specimens were collected from children and adults with acute gastroenteritis in six provinces in Thailand. RVAs were detected in 514/1867(27.5%) stool specimens. G1P[8] (44.7%) was the most predominant genotype, followed by G3P[8] (33.7%), G2P[4] (11.5%), G8P[8] (7.0%), and G9P[8] (1.3%). Unusual G3P[9] (0.8%), G3P[10] (0.4%), G4P[6] (0.4%), and G10P[14] (0.2%) were also detected at low frequencies. The predominant genotype, G1P[8] (64.4%), in 2014 decreased to 6.1% in 2016. In contrast, the frequency of G3P[8] markedly increased from 5.5% in 2014 to 65.3% in 2015 and 89.8% in 2016. On polyacrylamide gel electrophoresis, most (135/140; 96.4%) of the G3P[8] strains exhibited a short RNA profile. Successful determination of the nucleotide sequences of the VP7 genes of 98 G3P[8] strains with a short RNA profile showed that they are all equine-like G3P[8] strains. On phylogenetic analysis of genome segments of two representative Thai equine-like G3P[8] strains, it was noteworthy that they possessed distinct NSP4 genes, one bovine-like and the other human-like. Thus, we found that characteristic equine-like G3P[8] strains with a short RNA electropherotype are becoming highly prevalent in children and adults in Thailand.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): http://nih.dmsc.moph.go.th/research/showimgdetil.php?id=566
เผยแพร่โดย (EN): 1 National Institute of Health, Department of Medical Sciences, Nonthaburi, Thailand 2 Department of Virology and Parasitology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan 3 Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi, Japan 4 Center for Research Promotion and Support, Joint Research Support Promotion Facility, Fujita Health University, Toyoake, Aichi, Japan 5 Department of Medical Sciences, Medical Sciences Technical Office, Nonthaburi, Thailand 6 Thailand-Japan Research Collaboration Center on Emerging and Re-emerging Infections, Nonthaburi, Thailand 7 Osaka Institute of Public Health, Osaka, Japan
คำสำคัญ (EN): Rotavirus
เจ้าของลิขสิทธิ์ (EN): National Institute of Health, Department of Medical Science
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High prevalence of equine‐like G3P[8] rotavirus in children and adults with acute gastroenteritis in Thailand
Ratana Tacharoenmuang
1 National Institute of Health, Department of Medical Sciences, Nonthaburi, Thailand 2 Department of Virology and Parasitology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan 3 Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi, Japan 4 Center for Research Promotion and Support, Joint Research Support Promotion Facility, Fujita Health University, Toyoake, Aichi, Japan 5 Department of Medical Sciences, Medical Sciences Technical Office, Nonthaburi, Thailand 6 Thailand-Japan Research Collaboration Center on Emerging and Re-emerging Infections, Nonthaburi, Thailand 7 Osaka Institute of Public Health, Osaka, Japan
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