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High prevalence of G3P[8] rotavirus strains with a short electropherotype in acute gastroenteritis cases in Thailand
Tacharoenmuang - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): High prevalence of G3P[8] rotavirus strains with a short electropherotype in acute gastroenteritis cases in Thailand
ผู้แต่ง / หัวหน้าโครงการ (EN): Tacharoenmuang
บทคัดย่อ (EN): Background: Group A rotavirus (RVA) is a leading cause of severe diarrhea in infants and young children. RVA is also a major cause of death in young children, especially in developing countries in Africa and Asia. In Thailand, the rotavirus detection rate in hospitalized children with gastroenteritis ranges 28.4 to 44.5%. In this study, we surveyed the GP type distribution in Thailand. Materials and Methods: A total of 1,726 stool specimens were collected between January 2014 and September 2016 from diarrhea cases in 5 acute gastroenteritis sentinel sites in Bangkok, Udonthani, Phuket, Tak and Chanthaburi Provinces. The specimens were subjected to conventional RT-PCR to assign their G and P genotypes. Results: RVA was detected in 498/1,726 (28.8%) stool specimens. G1P[8] (12.4%) was the most predominant genotype, followed by G3P[8] (10.5%), G2P[4] (3.2%), G8P[8] (2.1%), G3P[9] (0.2%), G4P[6] (0.1%), G9P[8] (0.1%), G3P[6] (0.05%), G8P[4] (0.05%), and G8P[9] (0.05%). In 2014, the predominant genotype was G1P[8], and then the genotype shift from G1P[8] to G3P[8] was found in 2015. RVA gastroenteritis cases in Thailand were detected all-year round with high rates in November to April in 2014 and 2016. However, there was another peak of rotavirus gastroenteritis in July and August in 2015. The polyacrylamide gel electrophoresis analysis showed that the G3P[8] strains in this study had short RNA electropherotype. Discussion: These G3P[8] strains are novel intergenogroup reassortant strains with a short electropherotype which have emerged in Thailand and Australia since 2013. More recently, those reassortant strains were detected also in Europe and South America. This study showed the high prevalence of G3P[8] intergenogroup reassortant strains in Thailand.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): http://nih.dmsc.moph.go.th/research/showimgdetil.php?id=644
เผยแพร่โดย (EN): 1 National Institute of Health, Department of Medical Sciences, Nonthaburi, Thailand 2 Department of Virology and Parasitology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan 3 Medical Sciences Technical Office, Department of Medical Sciences, Nonthaburi, Thailand 4 Research Institute of Microbial Diseases, Osaka University, Japan 5 Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi, Japan 6 Thailand-Japan Research Collaboration Center on Emerging and Re-emerging Infections, Nonthaburi, Thailand
คำสำคัญ (EN): High prevalence
เจ้าของลิขสิทธิ์ (EN): National Institute of Health, Department of Medical Science
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High prevalence of G3P[8] rotavirus strains with a short electropherotype in acute gastroenteritis cases in Thailand
Tacharoenmuang
1 National Institute of Health, Department of Medical Sciences, Nonthaburi, Thailand 2 Department of Virology and Parasitology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan 3 Medical Sciences Technical Office, Department of Medical Sciences, Nonthaburi, Thailand 4 Research Institute of Microbial Diseases, Osaka University, Japan 5 Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi, Japan 6 Thailand-Japan Research Collaboration Center on Emerging and Re-emerging Infections, Nonthaburi, Thailand
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