สืบค้นงานวิจัย
Characterisation of Invasive Streptococcus pneumoniae Isolated from Cambodian Children between 2007-2012
Moore C.E. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Characterisation of Invasive Streptococcus pneumoniae Isolated from Cambodian Children between 2007-2012
ผู้แต่ง / หัวหน้าโครงการ (EN): Moore C.E.
บทคัดย่อ (EN): The 13-valent pneumococcal vaccine (PCV13) was introduced in Cambodia in January 2015. There are limited data concerning the common serotypes causing invasive pneumococcal disease (IPD). Knowledge of the circulating pneumococcal serotypes is important to monitor epidemiological changes before and after vaccine implementation. Methods All episodes of IPD defined by the isolation of Streptococcus pneumoniae from blood, cerebrospinal fluid or other sterile site in Cambodian children admitted to the Angkor Hospital for Children in Siem Reap, Northwestern Cambodia, between 1st January 2007 and 1st July 2012 were retrospectively studied. Streptococcus pneumoniae isolates that could be retrieved underwent phenotypic typing and whole genome sequencing. Results There were 90 Cambodian children hospitalized with IPD with a median (IQR) age of 2.3 years (0.9-6.2). The case fatality was 15.6% (95% CI 8-23). Of 50 Streptococcus pneumoniae isolates available for further testing, 46% were penicillin non-susceptible and 8% were ceftriaxone non-susceptible, 78% were cotrimoxazole resistant, 30% were erythromycin resistant and 30% chloramphenicol resistant. There were no significant changes in resistance levels over the five-year period. The most common serotypes were 1 (11/50; 22%), 23F (8/50; 16%), 14 (6/50; 12%), 5 (5/50; 10%) and 19A (3/50; 6%). Coverage by PCV7, PCV10 and PCV13 was 44%, 76% and 92% respectively. We identified novel multilocus sequence types and resistotypes using whole genome sequencing. Conclusions This study suggests IPD is an important disease in Cambodian children and can have a significant mortality. PCV13 coverage of the serotypes determined in studied strains was high and consistent with another recent study. The phenotypic resistance patterns observed were similar to other regional studies. The use of whole genome sequencing in the present study provides additional typing and resistance information together with the description of novel sequence types and resistotypes. © 2016 Moore et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-84979684879&doi=10.1371%2fjournal.pone.0159358&partnerID=40&md5=e97e5793b34a5ea8b69843fed4cefa8c
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): infant
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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Moore C.E.. "Characterisation of Invasive Streptococcus pneumoniae Isolated from Cambodian Children between 2007-2012". ไม่ระบุหน่วยงาน. ม.ป.ป.

Moore C.E.. "Characterisation of Invasive Streptococcus pneumoniae Isolated from Cambodian Children between 2007-2012". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



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Characterisation of Invasive Streptococcus pneumoniae Isolated from Cambodian Children between 2007-2012
Moore C.E.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
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