สืบค้นงานวิจัย
The magnitude of obesity and metabolic syndrome among diabetic chronic kidney disease population: A nationwide study
Kittiskulnam P. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): The magnitude of obesity and metabolic syndrome among diabetic chronic kidney disease population: A nationwide study
ผู้แต่ง / หัวหน้าโครงการ (EN): Kittiskulnam P.
บทคัดย่อ (EN): Although the prevalence of obesity and metabolic syndrome (MetS) among dialysis patients has been exceeding than general population, little is known regarding obesity and MetS in non-dialysis chronic kidney disease (CKD). We aimed to find the magnitude of obesity and MetS and their associations with impaired renal function among type 2 diabetes mellitus (T2DM) patients. Methods A national survey of T2DM patients was collected in the Thai National Health Security Office database during 2014–5. The sampling frame was designated as distinct geographic regions throughout the country. A stratified two-stage cluster sampling was used to select the study population. Anthropometry and 12-hour fasting blood samples were obtained by trained personnel. BMI of 25 kg/m2 was classified as obesity. MetS was defined as having elevated waist circumference (>90 and >80 cm in men and women, respectively) plus any two of the followings: triglyceride 150 mg/dL, HDL-C <40 in men or <50 mg/dL in women, blood pressure 130/85 mmHg, and fasting blood sugar 100 mg/dL. CKD was defined as an impaired renal function (eGFR <60 mL/min/1.73m2 according to the CKD-EPI equation). Logistic regression analysis was performed to examine the relationship between obesity and MetS with the presence of CKD. Results A total of 32,616 diabetic patients were finally recruited from 997 hospitals. The mean age was 61.5±10.9 years with 67.5% women. Of the participants, 35.4% were CKD patients. The prevalence of obesity was 46.5% in CKD and 54.1% in non-CKD patients with T2DM (p<0.001). In contrast, the prevalence of MetS in CKD patients was higher than their non-CKD counterparts (71.3 vs 68.8%, p<0.001). Moreover, there was an association between the prevalence of MetS with CKD stage from 3a to 5 (70.1, 72.3, 73.4, and 72.7%, respectively, p trend = 0.02). MetS, but not obesity, had a significant association with CKD in T2DM patients after adjusting for age, sex, and comorbidities [OR 1.14; 95% CI 1.06–1.22, p<0.001]. When stratified by each component of MetS, only high serum triglyceride and low HDL-C levels were increased in patients with CKD stage 4 and 5 compared with CKD stage 3 (p<0.001) and had a significant relationship with impaired renal function. Conclusion There were relatively high prevalences of both obesity and MetS in T2DM patients. A higher prevalence of MetS, but lower prevalence of obesity, was observed among diabetic CKD group compared with their non-CKD counterparts. MetS, as a surrogate of insulin resistance, appeared to be more important than obesity in the development of impaired renal function in diabetic population. © 2018 Kittiskulnam et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-85046818191&doi=10.1371%2fjournal.pone.0196332&partnerID=40&md5=c98f621c60fe6d64f361455474fdd27d
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Waist Circumference
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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Kittiskulnam P.. "The magnitude of obesity and metabolic syndrome among diabetic chronic kidney disease population: A nationwide study". ไม่ระบุหน่วยงาน. ม.ป.ป.

Kittiskulnam P.. "The magnitude of obesity and metabolic syndrome among diabetic chronic kidney disease population: A nationwide study". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



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The magnitude of obesity and metabolic syndrome among diabetic chronic kidney disease population: A nationwide study
Kittiskulnam P.
มหาวิทยาลัยมหิดล
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