สืบค้นงานวิจัย
Pathogenicity of genetically similar, H5N1 highly pathogenic avian influenza virus strains in chicken and the differences in sensitivity among different chicken breeds
Matsuu A. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Pathogenicity of genetically similar, H5N1 highly pathogenic avian influenza virus strains in chicken and the differences in sensitivity among different chicken breeds
ผู้แต่ง / หัวหน้าโครงการ (EN): Matsuu A.
บทคัดย่อ (EN): Differences in the pathogenicity of genetically closely related H5N1 highly pathogenic avian influenza viruses (HPAIVs) were evaluated in White Leghorn chickens. These viruses varied in the clinical symptoms they induced, including lethality, virus shedding, and replication in host tissues. A comparison of the host responses in the lung, brain, and spleen suggested that the differences in viral replication efficiency were related to the host cytokine response at the early phase of infection, especially variations in the proinflammatory cytokine IL-6. Based on these findings, we inoculated the virus that showed the mildest pathogenicity among the five tested, A/pigeon/Thailand/VSMU-7-NPT/2004, into four breeds of Thai indigenous chicken, Phadu-Hung-Dang (PHD), Chee, Dang, and Luang-Hung-Khao (LHK), to explore effects of genetic background on host response. Among these breeds, Chee, Dang, and LHK showed significantly longer survival times than White Leghorns. Virus shedding from dead Thai indigenous chickens was significantly lower than that from White Leghorns. Although polymorphisms were observed in the Mx and MHC class I genes, there was no significant association between the polymorphisms in these loci and resistance to HPAIV. © 2016 Matsuu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-84963976331&doi=10.1371%2fjournal.pone.0153649&partnerID=40&md5=9d51d088a98cd9f4cd5464adf507681d
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Virus Shedding
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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Matsuu A.. "Pathogenicity of genetically similar, H5N1 highly pathogenic avian influenza virus strains in chicken and the differences in sensitivity among different chicken breeds". ไม่ระบุหน่วยงาน. ม.ป.ป.

Matsuu A.. "Pathogenicity of genetically similar, H5N1 highly pathogenic avian influenza virus strains in chicken and the differences in sensitivity among different chicken breeds". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



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Pathogenicity of genetically similar, H5N1 highly pathogenic avian influenza virus strains in chicken and the differences in sensitivity among different chicken breeds
Matsuu A.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
Modeling the dynamics of backyard chicken flows in traditional trade networks in Thailand: Implications for surveillance and control of avian influenza A long-term serosurvey of avian influenza H5 among wild birds in Nakhon Sawan Province, Thailand Sensitivity improvement of immunochromatographic strip test for infectious myonecrosis virus detection Effects of semen collection frequency on semen quantity and quality in Betong Chicken and Dang chicken Phylogenetic analysis in various chicken strains inferred from mtDNA D-loop information Comparative Study on Cholesterol Level in Plasma of Crossbred Chicken from Pradu-Hangdam MKb. 55 Sire and Layer chicken Dam P2Y 6 receptors are involved in mediating the effect of inactivated avian influenza virus H5N1 on IL-6 & CXCL8 mRNA expression in respiratory epithelium Poultry farm vulnerability and risk of avian influenza re-emergence in Thailand Left-right asymmetry in chicken embryonic gonads Rab5, an early endosomal protein required for yellow head virus infection of Penaeus monodon
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