สืบค้นงานวิจัย
Mouse model of cat allergic rhinitis and intranasal liposome-adjuvanted refined Fel d 1 vaccine
Tasaniyananda N. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Mouse model of cat allergic rhinitis and intranasal liposome-adjuvanted refined Fel d 1 vaccine
ผู้แต่ง / หัวหน้าโครงการ (EN): Tasaniyananda N.
บทคัดย่อ (EN): Cats (Felis domesticus) are rich source of airborne allergens that prevailed in the environment and sensitized a number of people to allergy. In this study, a mouse model of allergic rhinitis caused by the cat allergens was developed for the first time and the model was used for testing therapeutic efficacy of a novel intranasal liposome-entrapped vaccines made of native Fel d 1 (major cat allergen) in comparison with the vaccine made of crude cat hair extract (cCE). BALB/c mice were sensitized with cCE mixed with alum intraperitoneally and intranasally. The allergic mice were treated with eight doses of either liposome (L)- entrapped native Fel d 1 (L-nFD1), L-cCE), or placebo on every alternate day. Vaccine efficacy evaluation was performed one day after provoking the treated mice with aerosolic cCE. All allergenized mice developed histological features of allergic rhinitis with rises of serum specific-IgE and Th2 cytokine gene expression. Serum IgE and intranasal mucus production of allergic mice reduced significantly after vaccination in comparison with the placebo mice. The vaccines also caused a shift of the Th2 response (reduction of Th2 cytokine expressions) towards the non-pathogenic responses: Th1 (down-regulation of the Th1 suppressive cytokine gene, IL-35) and Treg (up-regulation of IL-10 and TGF-β). In conclusions, a mouse model of allergic rhinitis to cat allergens was successfully developed. The intranasal, liposome-adjuvanted vaccines, especially the refined single allergen formulation, assuaged the allergic manifestations in the modeled mice. The prototype vaccine is worthwhile testing further for clinical use in the pet allergic patients. © 2016 Tasaniyananda et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-84961138850&doi=10.1371%2fjournal.pone.0150463&partnerID=40&md5=0d0db606373de9267c501d1cc0f3b75d
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Vaccines
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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Tasaniyananda N.. "Mouse model of cat allergic rhinitis and intranasal liposome-adjuvanted refined Fel d 1 vaccine". ไม่ระบุหน่วยงาน. ม.ป.ป.

Tasaniyananda N.. "Mouse model of cat allergic rhinitis and intranasal liposome-adjuvanted refined Fel d 1 vaccine". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



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Mouse model of cat allergic rhinitis and intranasal liposome-adjuvanted refined Fel d 1 vaccine
Tasaniyananda N.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
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