คลังข้อมูลการวิจัยการเกษตรไทย

ผู้แต่ง Siriphan Saeng-aroon

เผยแพร่โดย

1 National Institute of Health, Department of Medical Science, Ministry of Public Health, Nonthaburi, Thailand. 2 Bureau of Epidemiology, Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand. 3 Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan. 4 Research Institute of Microbial Diseases, Osaka University, Osaka, Japan. 5 Thailand-Japan Research Collaboration Center on Emerging and Re-emerging Infections (RCC-ERI), Nonthaburi, Thailand.

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งานวิจัยที่แนะนำ External Quality Assessment Scheme for HIV-1 Drug Resistance Genotyping in Thailand National Survey of Pretreatment HIV-Drug Resistance in Thai HIV-1-Infected Adults Use of dried blood spot specimens for in-house HIV drug resistance genotyping assay among infants in Thailand Prevalence of Protective Immunity for Diphtheria, Measles and Rubella among Myanmar, Cambodian and Laos Migrant Workers in Thailand HIV Drug Resistance among Pre-treatment Cases in Thailand: Four Rounds of Surveys during 2006-2013 Prevalence of zoonotic Bartonella species among rodents and shrews in Thailand The dynamics of norovirus genotypes and genetic analysis of a novel recombinant GII.P12-GII.3 among infants and children in Bangkok, Thailand between 2014 and 2016. การพัฒนาชุดตรวจและการศึกษาความชุกของการดื้อยาต้านไวรัสเอชไอวีในเด็กทารกในประเทศไทย Kit Development and Prevalence of HIV Drug Resistance in Infants in Thailand Prevalence of ocular demodicosis among patients at Tertiary Care Center, Bangkok, Thailand Whole-genome sequence analysis of Zika virus isolated from the plasma of an infected patient in Thailand

คัดลอก URL

ชื่อเรื่อง (EN):	Circulation of HIV-1 Multiple Complexity Recombinant Forms Among Female Sex Workers Recently Infected with HIV-1 in Thailand
ผู้แต่ง / หัวหน้าโครงการ (EN):	Siriphan Saeng-aroon
บทคัดย่อ (EN):	The circulating subtype distribution of HIV-1 has not been well characterized in female sex worker (FSW) populations in Thailand. To understand the mechanisms and interrelationships of epidemics involving FSWs in Thailand, we performed a large molecular epidemiological study of FSWs aged 25 years with recently acquired HIV-1 infections. The samples were collected in 2005, 2007, 2009, and 2011 in 38 provinces, representing every region of Thailand. After gag (p24), pol (pro-RT), and env (C2/V3) were sequenced, comprehensive genome analysis was performed. Genetic subtypes were determined in 159 plasma samples. The percentage of circulating recombinant forms (CRFs) CRF01_AE (90.6%) predominated, while subtype B (1.3%), other CRFs (1.9%), and unique recombinant forms (URFs) (6.2%) were identified as minor populations. Interestingly, the unique recombinant nature of these HIV-1 strains was verified in 10 specimens, indicating the presence of new forms of HIV-1 intersubtypes G/A, C/B, AE/B/C, and AE/B with different recombination breakpoints. Subtype B has contributed to these new generations of unique CRF01/B recombinants, especially in the pol (RT) gene, in which the template switching of the RT genomes occurred during reverse transcription. These results imply that the several unique recombinant viruses circulating in Thailand were probably generated in the population or introduced from neighboring countries. Our study helps clarify the patterns of viral transmission and define transmission pathways in Thailand.
บทคัดย่อ:	ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN):	en
เอกสารแนบ (EN):	http://nih.dmsc.moph.go.th/research/showimgdetil.php?id=482
เผยแพร่โดย (EN):	1 National Institute of Health, Department of Medical Science, Ministry of Public Health, Nonthaburi, Thailand. 2 Bureau of Epidemiology, Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand. 3 Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan. 4 Research Institute of Microbial Diseases, Osaka University, Osaka, Japan. 5 Thailand-Japan Research Collaboration Center on Emerging and Re-emerging Infections (RCC-ERI), Nonthaburi, Thailand.
คำสำคัญ (EN):	HIV-1 in Thailand
เจ้าของลิขสิทธิ์ (EN):	National Institute of Health, Department of Medical Science