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Actin interacts with dengue virus 2 and 4 envelope proteins
Jitoboam K. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Actin interacts with dengue virus 2 and 4 envelope proteins
ผู้แต่ง / หัวหน้าโครงการ (EN): Jitoboam K.
บทคัดย่อ (EN): Dengue virus (DENV) remains a significant public health problem in many tropical and subtropical countries worldwide. The DENV envelope (E) protein is the major antigenic determinant and the protein that mediates receptor binding and endosomal fusion. In contrast to some other DENV proteins, relatively few cellular interacting proteins have been identified. To address this issue a co-immuoprecipitation strategy was employed. The predominant co-immunoprecipitating proteins identified were actin and actin related proteins, however the results suggested that actin was the only bona fide interacting partner. Actin was shown to interact with the E protein of DENV 2 and 4, and the interaction between actin and DENV E protein was shown to occur in a truncated DENV consisting of only domains I and II. Actin was shown to decrease during infection, but this was not associated with a decrease in gene transcription. Actin-related proteins also showed a decrease in expression during infection that was not transcriptionally regulated. Cytoskeletal reorganization was not observed during infection, suggesting that the interaction between actin and E protein has a cell type specific component. © 2016 Jitoboam et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-84962106655&doi=10.1371%2fjournal.pone.0151951&partnerID=40&md5=968287fc8e4c898a1ffac71aefac801e
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Viral Envelope Proteins
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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Actin interacts with dengue virus 2 and 4 envelope proteins
Jitoboam K.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
Emergence of genotype Cosmopolitan of dengue virus type 2 and genotype III of dengue virus type 3 in Thailand Sensitivity improvement of immunochromatographic strip test for infectious myonecrosis virus detection Adaptor protein 1A facilitates dengue virus replication Potent neutralizing human monoclonal antibodies preferentially target mature dengue virus particles: Implication for novel strategy for dengue vaccine Relationships between dengue virus infection in mosquito vector, (Aedes aegypti), dengue cases and weather conditions in Samut Sakhon Province, Thailand Characterization of human CD8 T cell responses in dengue virus-infected patients from India Monitoring arbovirus in Thailand: Surveillance of dengue, chikungunya and zika virus, with a focus on coinfections Microparticles provide a novel biomarker to predict severe clinical outcomes of dengue virus infection Yellow head virus binding to cell surface proteins from Penaeus monodon hemocytes Antibody response to Zika and Dengue virus among the Zika realtime PCR positive cases in Thailand, 2016
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