สืบค้นงานวิจัย
Review of disease-related complications and management in adult patients with thalassemia: A multi-center study in Thailand
Chuncharunee S. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Review of disease-related complications and management in adult patients with thalassemia: A multi-center study in Thailand
ผู้แต่ง / หัวหน้าโครงการ (EN): Chuncharunee S.
บทคัดย่อ (EN): Disease-related complications and management are different among patients with thalassemia. This study was aimed to review the prevalence, clinical risk factors for the complications and the management in patients with thalassemia in Thailand. A multicenter cross-sectional study was conducted in patients with thalassemia aged 18 years old. Thalassemia-related complications and management were reviewed. The clinical parameters significantly associated with the complications were analyzed by logistic regression methods. The prevalence of thalassemia-related complications was 100% in patients with transfusion-dependent thalassemia (TDT) and 58.8% in patients with non-transfusion-dependent thalassemia (NTDT). Advanced age was statistically associated with extramedullary hematopoiesis in both TDT and NTDT patients. Splenectomy was a significant risk factor for pulmonary hypertension in both groups of patients. Severe iron overload started earlier in patients with TDT than NTDT and was associated with diabetes mellitus (adjusted odds ratio (AOR) = 6.2, p-value = 0.02). Disease-related complications are more prevalent in patients with TDT than patients with NTDT. Splenectomy and advanced age were important risk factors for developing major complications in both groups. Early screening and management for specific disease-related complications should be considered in patients with thalassemia according to their clinical risk factors. © 2019 Chuncharunee et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-85063347029&doi=10.1371%2fjournal.pone.0214148&partnerID=40&md5=7bda3c2547db955ab4117a67be7ca9b4
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): thrombosis
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
หากไม่พบเอกสารฉบับเต็ม (Full Text) โปรดติดต่อหน่วยงานเจ้าของข้อมูล

การอ้างอิง

Chuncharunee S.. "Review of disease-related complications and management in adult patients with thalassemia: A multi-center study in Thailand". ไม่ระบุหน่วยงาน. ม.ป.ป.

Chuncharunee S.. "Review of disease-related complications and management in adult patients with thalassemia: A multi-center study in Thailand". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



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Review of disease-related complications and management in adult patients with thalassemia: A multi-center study in Thailand
Chuncharunee S.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
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