คลังข้อมูลการวิจัยการเกษตรไทย

ผู้แต่ง Jurai Wongsawat

เผยแพร่โดย

1 Bamrasnaradura Infectious Diseases Institute, Department of Diseases Control, Ministry of Public Health, Nonthaburi, Thailand; 2 National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand

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งานวิจัยที่แนะนำ Method verification of Isolated Chicken Eye Test Efficacy Evaluation Test 15min Genotype diversity of human rotaviruses in hospitalized gastroenteritis cases in children and adults in Thailand during August 2017 - March 2018 Zika virus infection modulates the metabolomic profile of microglial cells Antibody response to Zika and Dengue virus among the Zika realtime PCR positive cases in Thailand, 2016 Monitoring arbovirus in Thailand: Surveillance of dengue, chikungunya and zika virus, with a focus on coinfections Viral infections in tilapines: More than just tilapia lake virus Biology of Zika virus infection in human skin cells Comparing interferon-gamma release assays to tuberculin skin test in thai children with tuberculosis exposure Dynamics of Zika virus outbreaks: An overview of mathematical modeling approaches

คัดลอก URL

ชื่อเรื่อง (EN):	Serological Differences after Acute Zika Virus Infections between Children and Adults: Implication for Use of a Serological Test
ผู้แต่ง / หัวหน้าโครงการ (EN):	Jurai Wongsawat
บทคัดย่อ (EN):	Information is limited regarding differential serological responses after acute Zika virus (ZIKV) infections and prevalence of cross-reactivity with anti-dengue virus (DENV) assays comparing children and adults. Early convalescent sera from a cohort of suspected mild DENV cases between December 2016 and September 2018 at Bamrasnaradura Infectious Diseases Institute in Thailand were tested for nonstructural protein 1 (NS1)–based anti-ZIKV IgM and IgG ELISAs (Euroimmun), and in-house anti-DENV IgM- and IgG-capture ELISAs. ZIKV cases were identified by positive real-time reverse transcriptase-polymerase chain reaction on urine. Sera from 26 (10 children and 16 adults) ZIKV and 237 (153 children and 74 adults) non-ZIKA cases collected at the median duration of 18 days (interquartile range [IQR] 18,19) post-onset of symptoms were tested. Comparing pediatric ZIKV to adult ZIKV cases, the mean anti-ZIKV IgM ratio was higher (2.12 versus 1.27 units, respectively; P = 0.07), whereas mean anti-ZIKV IgG ratio was lower (3.13 versus 4.24 units, respectively; P = 0.03). Sensitivity of anti-ZIKV IgM and specificity of anti-ZIKV IgG in pediatric ZIKV were higher than in adult ZIKV cases (80.0% versus 43.7% and 79.1% versus 43.2%, respectively). No cross-reactivity with anti-DENV IgM- and IgG-capture ELISA were reported in pediatric ZIKV cases in our study, whereas 25% and 12.5% were found in adult ZIKV cases, respectively. Age-related ZIKV serological differences have been observed. Positive NS1-based anti-ZIKV IgM and IgG ELISA at the early convalescent phase could be useful for ZIKV diagnosis in children, even in a dengue endemic setting.
บทคัดย่อ:	ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN):	en
เอกสารแนบ (EN):	http://nih.dmsc.moph.go.th/research/showimgdetil.php?id=756
เผยแพร่โดย (EN):	1 Bamrasnaradura Infectious Diseases Institute, Department of Diseases Control, Ministry of Public Health, Nonthaburi, Thailand; 2 National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand
คำสำคัญ (EN):	Serological test
เจ้าของลิขสิทธิ์ (EN):	National Institute of Health, Department of Medical Science