สืบค้นงานวิจัย
Rapid clinical assessment to facilitate the triage of adults with falciparum malaria, a retrospective analysis
Hanson J. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Rapid clinical assessment to facilitate the triage of adults with falciparum malaria, a retrospective analysis
ผู้แต่ง / หัวหน้าโครงการ (EN): Hanson J.
บทคัดย่อ (EN): Most adults dying from falciparum malaria will die within 48 hours of their hospitalisation. An essential component of early supportive care is the rapid identification of patients at greatest risk. In resource-poor settings, where most patients with falciparum malaria are managed, decisions regarding patient care must frequently be made using clinical evaluation alone. Methods: We retrospectively analysed 4 studies of 1801 adults with severe falciparum malaria to determine whether the presence of simple clinical findings might assist patient triage. Results: If present on admission, shock, oligo-anuria, hypo- or hyperglycaemia, an increased respiratory rate, a decreased Glasgow Coma Score and an absence of fever were independently predictive of death. The variables were used to construct a simple clinical algorithm. When applied to the 1801 patients, this algorithm's positive predictive value for survival to 48 hours was 99.4 (95% confidence interval (CI) 97.8-99.9) and for survival to discharge 96.9% (95% CI 94.3-98.5). In the 712 patients receiving artesunate, the algorithm's positive predictive value for survival to 48 hours was 100% (95% CI 97.3-100) and to discharge was 98.5% (95% CI 94.8-99.8). Conclusions: Simple clinical findings are closely linked to the pathophysiology of severe falciparum malaria in adults. A basic algorithm employing these indices can facilitate the triage of patients in settings where intensive care services are limited. Patients classified as low-risk by this algorithm can be safely managed initially on a general ward whilst awaiting senior clinical review and laboratory data. © 2014 Hanson et al.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-84900425990&doi=10.1371%2fjournal.pone.0087020&partnerID=40&md5=6e502a1a83b166d07b0df2bd6418ead1
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Shock
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
หากไม่พบเอกสารฉบับเต็ม (Full Text) โปรดติดต่อหน่วยงานเจ้าของข้อมูล

การอ้างอิง

Hanson J.. "Rapid clinical assessment to facilitate the triage of adults with falciparum malaria, a retrospective analysis". ไม่ระบุหน่วยงาน. ม.ป.ป.

Hanson J.. "Rapid clinical assessment to facilitate the triage of adults with falciparum malaria, a retrospective analysis". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



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Rapid clinical assessment to facilitate the triage of adults with falciparum malaria, a retrospective analysis
Hanson J.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
Defining surrogate endpoints for clinical trials in severe falciparum malaria Artemisinin-resistant Plasmodium falciparum malaria Streptococcus agalactiae infections and clinical relevance in adults, Thailand Perceptions of asymptomatic malaria infection and their implications for malaria control and elimination in Laos IgE low affinity receptor (CD23) expression, Plasmodium falciparum specific IgE and tumor necrosis factor-alpha production in Thai uncomplicated and severe falciparum malaria patients P. falciparum infection and maternofetal antibody transfer in malaria-endemic settings of varying transmission Inhibition of merozoite invasion and transient de-sequestration by sevuparin in humans with Plasmodium falciparum malaria Sequence variation in Plasmodium falciparum merozoite surface protein-2 is associated with virulence causing severe and cerebral malaria Adverse effects of Mefloquine for the treatment of uncomplicated malaria in Thailand: A pooled analysis of 19, 850 individual patients Quantifying connectivity between local Plasmodium falciparum malaria parasite populations using identity by descent
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