สืบค้นงานวิจัย
Dry Formulations Enhanced Mucoadhesive Properties and Reduced Cold Chain Handing of Influenza Vaccines
Saengkrit N. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Dry Formulations Enhanced Mucoadhesive Properties and Reduced Cold Chain Handing of Influenza Vaccines
ผู้แต่ง / หัวหน้าโครงการ (EN): Saengkrit N.
บทคัดย่อ (EN): To alleviate concerns in health security, emergency flu vaccine stockpiles are required for ensuring rapid availability of vaccines when needed. Cold chain preservation, at high cost and risk, is necessary to maintain vaccine efficacy. This study aimed to develop a dry, easily storable formula for influenza vaccine preparation. The formulation with mucoadhesive properties is expected to facilitate rapid delivery via nasal administration. Chitosan, a cationic polymer, was used as cryo-protectant and to promote mucoadhesion. Optimal concentrations and molecular weights of chitosan polymers were screened, with short chain chitosan (10 kDa) being most suitable. H1N1 dry powder, in different formulations, was prepared via freeze-drying. A series of cryo-protectants, trehalose (T), chitosan (C), fetal bovine serum (FBS; F), or a combination of these (TCF), were screened for their effects on prolonging vaccine shelf life. Physicochemical monitoring (particle size and zeta potential) of powders complexed with mucin revealed that the order of cryo-protectant mixing during preparation was of critical importance. Results indicated that the TCF formula retains its activity up to 1 year as indicated by TCID 50 analysis. This approach was also successful at prolonging the shelf life of H3N2 vaccine, and has the potential for large-scale implementation, especially in developed countries where long-term storage of vaccines is problematic. © 2018, American Association of Pharmaceutical Scientists.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-85053910582&doi=10.1208%2fs12249-018-1181-2&partnerID=40&md5=db5c04b13e9a12e585bc8b1f584a0008
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Refrigeration
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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Dry Formulations Enhanced Mucoadhesive Properties and Reduced Cold Chain Handing of Influenza Vaccines
Saengkrit N.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
Influenza neuraminidase subtype N1: Immunobiological properties and functional assays for specific antibody response Lipid composition of Hevea brasiliensis latex and dry rubber: characterization and relation with some physical properties Development of clade-specific and broadly reactive live attenuated influenza virus vaccines against rapidly evolving H5 subtype viruses Exploring the chemical space of influenza neuraminidase inhibitors Under-Flora in Rubber Plantations: Its Effect on Soil Properties Effect of roasting on phytochemical properties of Thai soybeans Chemical properties and sensory characteristics of tomyum puffed rice Structure and Thermal Properties of Polyurethanes Synthesized from Cardanol Diol Expanding NR Supply Chain for Indian Rubber Industry BIOMOLECULES CONTENTS AND RUBBER PROPERTIES OF SOME HEVEA BRASILIENSIS CLONES
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