คลังข้อมูลการวิจัยการเกษตรไทย

ผู้แต่ง Waralee Aksornchindarat

เผยแพร่โดย

1 Faculty of Medicine, Thammasat University, Pathumthani, Thailand. 2 National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand. 3 Division of Infectious Diseases, Faculty of Medicine, Thammasat University, Pathumthani, Thailand. Electronic address: thanak30@yahoo.com.

เผยแพร่เมื่อ ไม่ระบุวันที่เผยแพร่

หน่วยงาน ไม่ระบุหน่วยงาน

งานวิจัยที่แนะนำ T-SPOT.TB test and clinical risk scoring for diagnosis of latent tuberculosis infection among Thai healthcare workers T‑SPOT®.TB Test for Latent Tuberculosis infection Diagnosis and Treatment Guidance in Thai Health‑Care Professionals Tuberculin skin test and QuantiFERON®-TB Gold In-tube Test for diagnosing latent tuberculosis infection among Thai healthcare workers QuanFERON®-TB GOLD in-tUBE test for diagnosing latent tuberculosis infection among clinical-year Thai medical students Tuberculin skin test and QuantiFERON-TB Gold In-tube Test for latent tuberculosis in Thai HIV-infected adults Thai Cosmetopoeia การขับเคลื่อนเศรษฐกิจสังคมไทยด้วยการสร้างสรรคุณค่าเครื่องสำอางตามเอกลักษณ์ท้องถิ่น Thai Open GLAM QuantiFERON-TB Gold In-Tube Test for Tuberculosis Prevention in HIV-Infected Patients ปัจจัยเสี่ยงและอัตราการติดเชื้อวัณโรคแบบแฝงในกลุ่มบุคลากรทางการแพทย์ Risk factors and prevalence for latent tuberculosis infection among healthcare workers Genotyping of Mycobacterium tuberculosis by Spoligotyping การตรวจแยกสายพันธุ์เชื้อวัณโรคด้วยวิธี Spoligotyping

คัดลอก URL

ชื่อเรื่อง (EN):	T-SPOT®.TB test and clinical risk scoring for diagnosis of latent tuberculosis infection among Thai healthcare workers.
ผู้แต่ง / หัวหน้าโครงการ (EN):	Waralee Aksornchindarat
บทคัดย่อ (EN):	Background: Screening for latent tuberculosis infection (LTBI) is important to identify healthcare workers (HCWs) benefiting from preventive therapy. Interferon-gamma release assays (IGRAs) are sensitive and specific tests for LTBI diagnosis. However, in settings where IGRAs are not available, clinical risk assessment may be used as an alternative to diagnose LTBI. Methods: A cross-sectional study was conducted among HCWs of a tertiary-care university hospital in Thailand. All HCWs underwent T-SPOT®.TB test (T-SPOT) and assessment of LTBI clinical risks. Clinical risks associated with T-SPOT positivity were determined by multivariable logistic regression analysis and were given scores accordingly. The performance of the clinical risk scoring was evaluated in comparison to T-SPOT. Results: Among 140 enrolled HCWs, 125 (89%) were females, the median age was 27 years and 23 (16%) had T-SPOT positivity. Independent factors associated with T-SPOT positivity were age ≥30 years (adjusted odds ratio [aOR] 3.95; P = 0.002), working duration ≥60 months (aOR 3.75, P = 0.004) and frequency of TB contact ≥6 times (aOR 8.83, P = 0.005). The study's clinical risk scoring had the area under the curve by receiver operating curve analysis of 0.76 (P < 0.001) using T-SPOT positivity as a reference standard. The score of ≥3 had the best performance in diagnosing LTBI with sensitivity, specificity, positive predictive value and negative predictive value of 70%, 71%, 32% and 92%, respectively. Conclusions: In this setting where LTBI was prevalent among HCWs but IGRAs are not widely available, the clinical risk scoring may be used as an alternative to diagnose LTBI in HCW
บทคัดย่อ:	ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN):	en
เอกสารแนบ (EN):	http://nih.dmsc.moph.go.th/research/showimgdetil.php?id=763
เผยแพร่โดย (EN):	1 Faculty of Medicine, Thammasat University, Pathumthani, Thailand. 2 National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand. 3 Division of Infectious Diseases, Faculty of Medicine, Thammasat University, Pathumthani, Thailand. Electronic address: thanak30@yahoo.com.
คำสำคัญ (EN):	Spoligotyping.
เจ้าของลิขสิทธิ์ (EN):	National Institute of Health, Department of Medical Science