สืบค้นงานวิจัย
Quantifying connectivity between local Plasmodium falciparum malaria parasite populations using identity by descent
Taylor A.R. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Quantifying connectivity between local Plasmodium falciparum malaria parasite populations using identity by descent
ผู้แต่ง / หัวหน้าโครงการ (EN): Taylor A.R.
บทคัดย่อ (EN): With the rapidly increasing abundance and accessibility of genomic data, there is a growing interest in using population genetic approaches to characterize fine-scale dispersal of organisms, providing insight into biological processes across a broad range of fields including ecology, evolution and epidemiology. For sexually recombining haploid organisms such as the human malaria parasite P. falciparum, however, there have been no systematic assessments of the type of data and methods required to resolve fine scale connectivity. This analytical gap hinders the use of genomics for understanding local transmission patterns, a crucial goal for policy makers charged with eliminating this important human pathogen. Here we use data collected from four clinics with a catchment area spanning approximately 120 km of the Thai-Myanmar border to compare the ability of divergence (F ST ) and relatedness based on identity by descent (IBD) to resolve spatial connectivity between malaria parasites collected from proximal clinics. We found no relationship between inter-clinic distance and F ST , likely due to sampling of highly related parasites within clinics, but a significant decline in IBD-based relatedness with increasing inter-clinic distance. This association was contingent upon the data set type and size. We estimated that approximately 147 single-infection whole genome sequenced parasite samples or 222 single-infection parasite samples genotyped at 93 single nucleotide polymorphisms (SNPs) were sufficient to recover a robust spatial trend estimate at this scale. In summary, surveillance efforts cannot rely on classical measures of genetic divergence to measure P. falciparum transmission on a local scale. Given adequate sampling, IBD-based relatedness provides a useful alternative, and robust trends can be obtained from parasite samples genotyped at approximately 100 SNPs. © 2017 Taylor et al.
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ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-85033229868&doi=10.1371%2fjournal.pgen.1007065&partnerID=40&md5=997c420dd7057bafa3d76c272d429d4e
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Thailand
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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Taylor A.R.. "Quantifying connectivity between local Plasmodium falciparum malaria parasite populations using identity by descent". ไม่ระบุหน่วยงาน. ม.ป.ป.

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Quantifying connectivity between local Plasmodium falciparum malaria parasite populations using identity by descent
Taylor A.R.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
Artemisinin-resistant Plasmodium falciparum malaria Genetic diversity of plasmodium falciparum populations in malaria declining areas of Sabah, East Malaysia Inhibition of merozoite invasion and transient de-sequestration by sevuparin in humans with Plasmodium falciparum malaria Genetic diversity of the Plasmodium vivax multidrug resistance 1 gene in Thai parasite populations Sequence variation in Plasmodium falciparum merozoite surface protein-2 is associated with virulence causing severe and cerebral malaria Prevalence of Plasmodium falciparum molecular markers of antimalarial drug resistance in a residual malaria focus area in Sabah, Malaysia IgE low affinity receptor (CD23) expression, Plasmodium falciparum specific IgE and tumor necrosis factor-alpha production in Thai uncomplicated and severe falciparum malaria patients Differential roles of an Anopheline midgut GPI-anchored protein in mediating Plasmodium falciparum and Plasmodium vivax ookinete invasion Longitudinal genomic surveillance of Plasmodium falciparum malaria parasites reveals complex genomic architecture of emerging artemisinin resistance Hemoglobin e prevalence among ethnic groups residing in malaria-endemic areas of Northern Thailand and its lack of association with plasmodium falciparum invasion in vitro
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