สืบค้นงานวิจัย
pFAK-Y397 overexpression as both a prognostic and a predictive biomarker for patients with metastatic osteosarcoma
Thanapprapasr K. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): pFAK-Y397 overexpression as both a prognostic and a predictive biomarker for patients with metastatic osteosarcoma
ผู้แต่ง / หัวหน้าโครงการ (EN): Thanapprapasr K.
บทคัดย่อ (EN): Focal adhesion kinase (FAK) is important for tumor cell survival and metastasis in various cancers. However, its expression and prognostic value in patients with metastatic osteosarcoma remain unknown. We investigated the expression of FAK and its phosphorylated form (pFAK-Y397) in osteosarcoma tissues from 53 patients by immunohistochemistry and evaluated their correlations with clinicopathologic characteristics and outcomes. The prognostic values were assessed using Kaplan-Meier survival and Cox regression analyses. Total FAK and pFAK-Y397 were overexpressed in 48 (90.6%) and 33 (62.3%) cases, respectively. pFAK-Y397 overexpression was correlated with poor histologic response after neoadjuvant chemotherapy in patients with osteosarcoma regardless of the presence of metastasis or not. Kaplan-Meier curve showed that patients with metastatic osteosarcoma with pFAK-Y397 overexpression had significantly worse overall survival (OS) than those with non-overexpression (P = 0.044). Multivariate Cox regression analysis confirmed pFAK-Y397 overexpression as an independent prognostic predictor for OS and post metastases OS (PMOS) (P = 0.017, P = 0.006, respectively). Age at diagnosis was also an independent indicator for PMOS (P = 0.003). However, total FAK expression was not correlated with any clinicopathologic characteristics or OS in patients with metastatic osteosarcoma. In conclusion, our findings identified FAK as a common aberrant protein overexpression in various subtypes of osteosarcoma. pFAK-Y397 overexpression can be used as a prognostic biomarker predicting poor OS for patients with metastatic osteosarcoma, and the expression of pFAK-Y397 differentiated good and poor responders to neoadjuvant chemotherapy. © 2017 Thanapprapasr et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-85028548018&doi=10.1371%2fjournal.pone.0182989&partnerID=40&md5=8a3d811f7d20cf1e8a04d5460e0e2df5
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Young Adult
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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การอ้างอิง

Thanapprapasr K.. "pFAK-Y397 overexpression as both a prognostic and a predictive biomarker for patients with metastatic osteosarcoma". ไม่ระบุหน่วยงาน. ม.ป.ป.

Thanapprapasr K.. "pFAK-Y397 overexpression as both a prognostic and a predictive biomarker for patients with metastatic osteosarcoma". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



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pFAK-Y397 overexpression as both a prognostic and a predictive biomarker for patients with metastatic osteosarcoma
Thanapprapasr K.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
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