สืบค้นงานวิจัย
Identification of putative kdr mutations in the tropical bed bug, Cimex hemipterus (Hemiptera : Cimicidae)
Kai Dang - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Identification of putative kdr mutations in the tropical bed bug, Cimex hemipterus (Hemiptera : Cimicidae)
ผู้แต่ง / หัวหน้าโครงการ (EN): Kai Dang
บทคัดย่อ (EN): BACKGROUND Bed bugs [both Cimex hemipterus (F.) and Cimex lectularius L.] are highly resistant to pyrethroids worldwide. An important resistance mechanism known as ‘knockdown resistance’ (kdr) is caused by genetic point mutations on the voltage‐gated sodium channel (VGSC) gene. Previous studies have identified two point mutations (V419L and L925I) on the VGSC gene in C. lectularius that are responsible for kdr‐type resistance. However, the kdr mutations in C. hemipterus have not been investigated. RESULTS Four novel mutations, L899V (leucine to valine), M918I (methionine to isoleucine), D953G (aspartic acid to glycine) and L1014F (leucine to phenylalanine), were identified in the domain II region of the C. hemipterus VGSC gene. This region has been widely investigated for the study of kdr‐type resistance to pyrethroids in other insect pests. The V419L and L925I kdr mutations as previously identified in C. lectularius were not detected in C. hemipterus. CONCLUSION M918I and L1014F are considered to be probable kdr mutations and may play essential roles in kdr‐type resistance to pyrethroids in C. hemipterus. Further studies are under way in the authors' laboratory to determine the non‐kdr‐type resistance mechanisms in C. hemipterus. © 2014 Society of Chemical Industry
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): http://nih.dmsc.moph.go.th/research/showimgdetil.php?id=449
เผยแพร่โดย (EN): 1 Department of Medical Entomology, Institute for Clinical Pathology and Medical Research, Westmead Hospital, Westmead, NSW, Australia. 2 Institute of Entomology, College of Life Sciences, Nankai University, Tianjin, China. 3 Urban Entomology Laboratory, Vector Control Research Unit, School of Biological Sciences, Universiti Sains Malaysia, Penang, Malaysia. 4 Prior's Loft, Coleford Road, Tidenham, Monmouthshire, UK. 5 Department of Medical Sciences, National Institute of Health, Nonthaburi, Thailand.
คำสำคัญ (EN): Cimex hemipterus
เจ้าของลิขสิทธิ์ (EN): National Institute of Health, Department of Medical Science
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Identification of putative kdr mutations in the tropical bed bug, Cimex hemipterus (Hemiptera : Cimicidae)
Kai Dang
1 Department of Medical Entomology, Institute for Clinical Pathology and Medical Research, Westmead Hospital, Westmead, NSW, Australia. 2 Institute of Entomology, College of Life Sciences, Nankai University, Tianjin, China. 3 Urban Entomology Laboratory, Vector Control Research Unit, School of Biological Sciences, Universiti Sains Malaysia, Penang, Malaysia. 4 Prior's Loft, Coleford Road, Tidenham, Monmouthshire, UK. 5 Department of Medical Sciences, National Institute of Health, Nonthaburi, Thailand.
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