สืบค้นงานวิจัย
Contemporary survival of patients with pulmonary arterial hypertension and congenital systemic to pulmonary shunts
Vijarnsorn C. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Contemporary survival of patients with pulmonary arterial hypertension and congenital systemic to pulmonary shunts
ผู้แต่ง / หัวหน้าโครงการ (EN): Vijarnsorn C.
บทคัดย่อ (EN): Objective To compare survival of patients with newly diagnosed pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD) according to various clinical classifications with classifications of anatomical-pathophysiological systemic to pulmonary shunts in a single-center cohort. Methods All prevalent cases of PAH-CHD with hemodynamic confirmation by cardiac catheterization in 1995–2015 were retrospectively reviewed. Patients who were younger than three months of age, or with single ventricle following surgery were excluded. Baseline characteristics and clinical outcomes were retrieved from the database. The survival analysis was performed at the end of 2016. Prognostic factors were identified using multivariate analysis. Results A total of 366 consecutive patients (24.5 ± 17.6 years of age, 40% male) with PAH-CHD were analyzed. Most had simple shunts (85 pre-tricuspid, 105 post-tricuspid, 102 combined shunts). Patients with pre-tricuspid shunts were significantly older at diagnosis in comparison to post-tricuspid, combined, and complex shunts. Clinical classifications identified patients as having Eisenmenger syndrome (ES, 26.8%), prevalent left to right shunt (66.7%), PAH with small defect (3%), or PAH following defect correction (3.5%). At followup (median = 5.9 years; 0.1–20.7 years), no statistically significant differences in survival rate were seen among the anatomical-pathophysiological shunts (p = 0.1). Conversely, the clinical classifications revealed that patients with PAH-small defect had inferior survival compared to patients with ES, PAH post-corrective surgery, or PAH with prevalent left to right shunt (p = 0.01). Significant mortality risks were functional class III, age < 10 years, PAH-small defect, elevated right atrial pressure > 15 mmHg, and baseline PVR > 8 WU•m. 2 Conclusion Patients with PAH-CHD had a modest long-term survival. Different anatomical-pathophysiological shunts affect the natural presentation, while clinical classifications indicate treatment strategies and survival. Contemporary therapy improves survival in deliberately selected patients. © 2018 Vijarnsorn et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-85045680197&doi=10.1371%2fjournal.pone.0195092&partnerID=40&md5=8b9b8a7bac295dc0eb7ddc0a6d4a72d4
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Young Adult
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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Vijarnsorn C.. "Contemporary survival of patients with pulmonary arterial hypertension and congenital systemic to pulmonary shunts". ไม่ระบุหน่วยงาน. ม.ป.ป.

Vijarnsorn C.. "Contemporary survival of patients with pulmonary arterial hypertension and congenital systemic to pulmonary shunts". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



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Contemporary survival of patients with pulmonary arterial hypertension and congenital systemic to pulmonary shunts
Vijarnsorn C.
มหาวิทยาลัยมหิดล
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