คลังข้อมูลการวิจัยการเกษตรไทย

ผู้แต่ง Janisara Rudeeaneksin

เผยแพร่โดย

1 National Insti tute of Health, Department of Medical Sciences, Nonthaburi Province, Thailand. 2 Division of Bioresources, Hokkaido University Research Center for Zoonosis Control, Sapporo, Japan. 3 International Collaboration Unit, Hokkaido University Research Center for Zoonosis Control, Sapporo, Japan. 4 The Office of Disease Prevention and Control 5thRatchaburi, Department of Disease Control, Thailand.

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งานวิจัยที่แนะนำ Group B Streptococcal bacteremia burden and trends over time, 2007-15, Thailand Full genome characterization of novel DS-1-like G9P[8] rotavirus strains that have emerged in Thailand Wolbachia supergroups A and B in natural populations of medically important filth flies (Diptera : Muscidae, Calliphoridae, and Sarcophagidae) in Thailand Prevalence of zoonotic Bartonella species among rodents and shrews in Thailand Draft Genome Sequence of a Clostridium botulinum Isolate from Thailand Harboring the Subtype bont/B8 Gene Circulation of HIV-1 Multiple Complexity Recombinant Forms Among Female Sex Workers Recently Infected with HIV-1 in Thailand Genotypic diversity of multidrug-, quinolone- and extensively drug-resistant Mycobacterium tuberculosis isolates in Thailand Whole-genome sequencing analysis of serially isolated multi-drug and extensively drug resistant Mycobacterium tuberculosis from Thai patients Mangrove forests in Thailand Progress on Rubber Breeding of Thailand

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ชื่อเรื่อง (EN):	Drug-resistant Mycobacterium tuberculosis and its genotypes isolated from an outbreak in western Thailand.
ผู้แต่ง / หัวหน้าโครงการ (EN):	Janisara Rudeeaneksin
บทคัดย่อ (EN):	Background: Multidrug-resistant TB (MDR-TB) outbreaks have occurred in the Thamaka district, Kanchanaburi province in Thailand. Methods: Seventy-two isolates, which included 7% mono-, 30.6% MDR and extensively drug-resistant TB (XDR-TB), were genotyped by spoligotyping, mycobacterial interspersed repetitive unit-variable-number tandem repeat (MIRU-VNTR) and single nucleotide polymorphism genotyping, and their drug resistance was analysed. Results: The spoligotyping results showed that Beijing spoligo-international type (SIT)1 was predominant (n=38; 52.8%) while the remaining were non-Beijing sublineages (n=34). The MIRU-VNTR analysis showed that Beijing isolates, most of which belonged to the modern type (n=37), formed 5 clusters and 13 individual patterns. In katG, only mutation Ser315Thr was identified. In rpoB, Ser531Leu was predominant, except for His526Arg and Leu533Pro, which were found in two isolates. A cluster of 14 Beijing strains contained these common mutations and shared the MIRU-VNTR genotype with isolates in the Thamaka district that had spread previously. Two U SIT523 isolates contained the mutations A1400G in rrs and Asp94Gly in gyrA genes, indicating a spread of XDR-TB. Conclusions: Most mutations were associated with drug resistance and the specific MDR Beijing and XDR-TB in U SIT523 isolates remain. This genotyping is a key tool for tracking TB transmission in the Thamaka district of Thailand.
บทคัดย่อ:	ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN):	en
เอกสารแนบ (EN):	http://nih.dmsc.moph.go.th/research/showimgdetil.php?id=762
เผยแพร่โดย (EN):	1 National Insti tute of Health, Department of Medical Sciences, Nonthaburi Province, Thailand. 2 Division of Bioresources, Hokkaido University Research Center for Zoonosis Control, Sapporo, Japan. 3 International Collaboration Unit, Hokkaido University Research Center for Zoonosis Control, Sapporo, Japan. 4 The Office of Disease Prevention and Control 5thRatchaburi, Department of Disease Control, Thailand.
คำสำคัญ (EN):	spoligotyping
เจ้าของลิขสิทธิ์ (EN):	National Institute of Health, Department of Medical Science