สืบค้นงานวิจัย
Evolution of Fseg/Cseg dimorphism in region III of the Plasmodium falciparum eba-175 gene
Yasukochi Y. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Evolution of Fseg/Cseg dimorphism in region III of the Plasmodium falciparum eba-175 gene
ผู้แต่ง / หัวหน้าโครงการ (EN): Yasukochi Y.
บทคัดย่อ (EN): The 175-kDa erythrocyte binding antigen (EBA-175) of the malaria parasite Plasmodium falciparum is important for its invasion into human erythrocytes. The primary structure of eba-175 is divided into seven regions, namely I to VII. Region III contains highly divergent dimorphic segments, termed Fseg and Cseg. The allele frequencies of segmental dimorphism within a P. falciparum population have been extensively examined; however, the molecular evolution of segmental dimorphism is not well understood. A comprehensive comparison of nucleotide sequences among 32 P. falciparum eba-175 alleles identified in our previous study, two Plasmodium reichenowi, and one P. gaboni orthologous alleles obtained from the GenBank database was conducted to uncover the origin and evolutionary processes of segmental dimorphism in P. falciparum eba-175. In the eba-175 nucleotide sequence derived from a P. reichenowi CDC strain, both Fseg and Cseg were found in region III, which implies that the original eba-175 gene had both segments, and deletions of F- and C-segments generated Cseg and Fseg alleles, respectively. We also confirmed the presence of allele with Fseg and Cseg in another P. reichenowi strain (SY57), by re-mapping short reads obtained from the GenBank database. On the other hand, the segmental sequence of eba-175 ortholog in P. gaboni was quite diverged from those of the other species, suggesting that the original eba-175 dimorphism of P. falciparum can be traced back to the stem linage of P. falciparum and P. reichenowi. Our findings suggest that Fseg and Cseg alleles are derived from a single eba-175 allele containing both segments in the ancestral population of P. falciparum and P. reichenowi, and that the allelic dimorphism of eba-175 was shaped by the independent emergence of similar dimorphic lineage in different species that has never been observed in any evolutionary mode of allelic dimorphism at other loci in malaria genomes. © 2017 Elsevier B.V.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-85011706120&doi=10.1016%2fj.meegid.2017.01.026&partnerID=40&md5=e009afa1a25589d57322dbbc9b6e8998
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Protozoan Proteins
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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การอ้างอิง

Yasukochi Y.. "Evolution of Fseg/Cseg dimorphism in region III of the Plasmodium falciparum eba-175 gene". ไม่ระบุหน่วยงาน. ม.ป.ป.

Yasukochi Y.. "Evolution of Fseg/Cseg dimorphism in region III of the Plasmodium falciparum eba-175 gene". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



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Evolution of Fseg/Cseg dimorphism in region III of the Plasmodium falciparum eba-175 gene
Yasukochi Y.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
Combinatorial Genetic Modeling of pfcrt-Mediated Drug Resistance Evolution in Plasmodium falciparum Artemisinin-resistant Plasmodium falciparum malaria Single nucleotide polymorphisms in Plasmodium falciparum V type H+ pyrophosphatase gene (pfvp2) and their associations with pfcrt and pfmdr1 polymorphisms Diversifying selection on the thrombospondin-related adhesive protein (TRAP) gene of plasmodium falciparum in Thailand Differential roles of an Anopheline midgut GPI-anchored protein in mediating Plasmodium falciparum and Plasmodium vivax ookinete invasion Inhibition of merozoite invasion and transient de-sequestration by sevuparin in humans with Plasmodium falciparum malaria Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance Effects of sevuparin on rosette formation and cytoadherence of Plasmodium falciparum infected erythrocytes Neutralizing antibodies against Plasmodium falciparum associated with successful cure after drug therapy Genetic diversity of the Plasmodium vivax multidrug resistance 1 gene in Thai parasite populations
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