สืบค้นงานวิจัย
HIV-1 envelope glycoproteins from diverse clades differentiate antibody responses and durability among vaccinees
Yates N.L. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): HIV-1 envelope glycoproteins from diverse clades differentiate antibody responses and durability among vaccinees
ผู้แต่ง / หัวหน้าโครงการ (EN): Yates N.L.
บทคัดย่อ (EN): Induction of broadly cross-reactive antiviral humoral responses with the capacity to target globally diverse circulating strains is a key goal for HIV-1 immunogen design. A major gap in the field is the identification of diverse HIV-1 envelope antigens to evaluate vaccine regimens for binding antibody breadth. In this study, we define unique antigen panels to map HIV-1 vaccine-elicited antibody breadth and durability. Diverse HIV-1 envelope glycoproteins were selected based on genetic and geographic diversity to cover the global epidemic, with a focus on sexually acquired transmitted/founder viruses with a tier 2 neutralization phenotype. Unique antigenicity was determined by nonredundancy (Spearman correlation), and antigens were clustered using partitioning around medoids (PAM) to identify antigen diversity. Cross-validation demonstrated that the PAM method was better than selection by reactivity and random selection. Analysis of vaccine-elicited V1V2 binding antibody in longitudinal samples from the RV144 clinical trial revealed the striking heterogeneity among individual vaccinees in maintaining durable responses. These data support the idea that a major goal for vaccine development is to improve antibody levels, breadth, and durability at the population level. Elucidating the level and durability of vaccine-elicited binding antibody breadth needed for protection is critical for the development of a globally efficacious HIV vaccine. © 2018 American Society for Microbiology.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-85044631722&doi=10.1128%2fJVI.01843-17&partnerID=40&md5=3d2c2efe5fd8f2b6922b820fa22b77ef
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): HIV Antibodies
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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Yates N.L.. "HIV-1 envelope glycoproteins from diverse clades differentiate antibody responses and durability among vaccinees". ไม่ระบุหน่วยงาน. ม.ป.ป.

Yates N.L.. "HIV-1 envelope glycoproteins from diverse clades differentiate antibody responses and durability among vaccinees". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



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HIV-1 envelope glycoproteins from diverse clades differentiate antibody responses and durability among vaccinees
Yates N.L.
มหาวิทยาลัยมหิดล
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