สืบค้นงานวิจัย
Bidirectional association between asthma and irritable bowel syndrome: Two population-based retrospective cohort studies
Shen T.-C. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Bidirectional association between asthma and irritable bowel syndrome: Two population-based retrospective cohort studies
ผู้แต่ง / หัวหน้าโครงการ (EN): Shen T.-C.
บทคัดย่อ (EN): There is a demonstrated association between asthma and irritable bowel syndrome (IBS). In this study, we examined the bidirectional association between asthma and IBS using a nationwide database. Methods: We conducted two retrospective cohort studies using data obtained from the National Health Insurance of Taiwan. Study 1 included 29,648 asthma patients newly diagnosed between 2000 and 2010. Study 2 included 29,875 IBS patient newly diagnosed between 2000 and 2010. For each study, four subjects without asthma and IBS were selected, respectively, frequency-matched by sex, age, and the diagnosis date. All four cohorts were followed up until the end of 2011 to estimate incident IBS for Study 1 and incident asthma for study 2. Adjusted hazard ratios (aHRs) were estimated using the Cox proportional hazards model after controlling for sex, age and comorbidities. Results: The incidence of IBS was 1.89 times higher in the asthma cohort than in the comparison cohort (8.26 vs. 4.36 per 1,000 person-years), with an aHR of 1.57 [95% confidence interval (CI) = 1.47-1.68]. The aHRs remained significant in all subgroups measured by sex, age and the presence of comorbidities. In contrast, the incidence of asthma was 1.76 times higher in the IBS cohort than the comparison cohort (7.09 vs. 4.03 per 1,000 person-years), with an aHR of 1.54 (95% CI = 1.44-1.64). Similarly, aHRs remained significant in all subgroups measured by sex, age and the presence of comorbidities. Conclusion: The present study suggests a bidirectional association between asthma and IBS. Atopy could be a shared pathophysiology underlying this association, deserving a further investigation. © 2016 Shen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-84964691819&doi=10.1371%2fjournal.pone.0153911&partnerID=40&md5=213ca9a3788dbda3fe9b3f88b24051f0
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Young Adult
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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Shen T.-C.. "Bidirectional association between asthma and irritable bowel syndrome: Two population-based retrospective cohort studies". ไม่ระบุหน่วยงาน. ม.ป.ป.

Shen T.-C.. "Bidirectional association between asthma and irritable bowel syndrome: Two population-based retrospective cohort studies". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



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Bidirectional association between asthma and irritable bowel syndrome: Two population-based retrospective cohort studies
Shen T.-C.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
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