สืบค้นงานวิจัย
Cryptic determinant of a4b7 binding in the v2 loop of hiv-1 gp120
Tassaneetrithep B. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Cryptic determinant of a4b7 binding in the v2 loop of hiv-1 gp120
ผู้แต่ง / หัวหน้าโครงการ (EN): Tassaneetrithep B.
บทคัดย่อ (EN): The peptide segment of the second variable loop of HIV-1 spanning positions 166-181 harbors two functionally important sites. The first, spanning positions 179-181, engages the human α4b7 integrin receptor which is involved in T-cell guthoming and may play a role in human immunodeficiency virus (HIV)-host cell interactions. The second, at positions 166-178, is a major target of anti-V2 antibodies elicited by the ALVAC/AIDSVAX vaccine used in the RV144 clinical trial. Notably, these two sites are directly adjacent, but do not overlap. Here, we report the identity of a second determinant of α4b7 binding located at positions 170-172 of the V2 loop. This segment - tripeptide QRV 170-172 - is located within the second site, yet functionally affects the first site. The absence of this segment abrogates α4b7 binding in peptides bearing the same sequence from position 173-185 as the V2 loops of the RV144 vaccines. However, peptides exhibiting V2 loop sequences from heterologous HIV-1 strains that include this QRV 170-172 motif bind the α4b7 receptor on cells. Therefore, the peptide segment at positions 166-178 of the V2 loop of HIV-1 viruses appears to harbor a cryptic determinant of α4b7 binding. Prior studies show that the anti-V2 antibody response elicited by the RV144 vaccine, along with immune pressure inferred from a sieve analysis, is directed to this same region of the V2 loop. Accordingly, the anti-V2 antibodies that apparently reduced the risk of infection in the RV144 trial may have functioned by blocking α4b7-mediated HIV-host cell interactions via this cryptic determinant.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-84907482263&doi=10.1371%2fjournal.pone.0108446&partnerID=40&md5=2643729d92ce4e488f09d97a5a2302f7
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Viral Load
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
หากไม่พบเอกสารฉบับเต็ม (Full Text) โปรดติดต่อหน่วยงานเจ้าของข้อมูล

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Tassaneetrithep B.. "Cryptic determinant of a4b7 binding in the v2 loop of hiv-1 gp120". ไม่ระบุหน่วยงาน. ม.ป.ป.

Tassaneetrithep B.. "Cryptic determinant of a4b7 binding in the v2 loop of hiv-1 gp120". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



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Cryptic determinant of a4b7 binding in the v2 loop of hiv-1 gp120
Tassaneetrithep B.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
Identification of new regions in HIV-1 gp120 Variable 2 and 3 Loops that Bind to α4β7 Integrin Receptor Characterization of HIV-1 gp120 antibody specificities induced in anogenital secretions of RV144 vaccine recipients after late boost immunizations Glycans flanking the hypervariable connecting peptide between the a and B strands of the V1/V2 domain of HIV-1 gp120 confer resistance to antibodies that neutralize CRF01-AE viruses Prevalence of HIV infection, access to HIV care, and response to antiretroviral therapy among partners of HIV-infected individuals in Thailand National Survey of Pretreatment HIV-Drug Resistance in Thai HIV-1-Infected Adults HIV-1- specific IgA monoclonal antibodies from an HIV-1 vaccinee mediate galactosylceramide blocking and phagocytosis Circulation of HIV-1 Multiple Complexity Recombinant Forms Among Female Sex Workers Recently Infected with HIV-1 in Thailand Identification of immunodominant cd4-restricted epitopes co-located with antibody binding sites in individuals vaccinated with ALVAC-HIV and AIDSVAX B/E Hepatitis B and C co-infection in HIV patients from the TREAT Asia HIV observational database: Analysis of risk factors and survival Practices in security and confidentiality of HIV/ AIDS patients’ information: A national survey among staff at HIV outpatient clinics in Vietnam
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