สืบค้นงานวิจัย
Two new anti-apoptotic proteins of white spot syndrome virus that bind to an effector caspase (PmCasp) of the giant tiger shrimp Penaeus (Penaeus) monodon
Lertwimol T. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Two new anti-apoptotic proteins of white spot syndrome virus that bind to an effector caspase (PmCasp) of the giant tiger shrimp Penaeus (Penaeus) monodon
ผู้แต่ง / หัวหน้าโครงการ (EN): Lertwimol T.
บทคัดย่อ (EN): White spot syndrome virus proteins WSSV134 and WSSV322 have been shown to bind with the p20 domain (residues 55-214) of Penaeus monodon caspase ( PmCasp) protein through yeast two-hybrid screening. Binding was confirmed for the p20 domain and the full-length caspase by co-immunoprecipitation. WSSV134 is also known as the WSSV structural protein VP36A, but no function or conserved domains have been ascribed to WSSV322. Discovery of the caspase binding activity of these two proteins led to an investigation of their possible anti-apoptotic roles. Full-length PmCasp was confirmed to be an effector caspase by inducing apoptosis in transfected Sf-9 cells as assessed by DAPI staining. Using the same cell model, comparison of cells co-transfected with PmCasp and either WSSV134 or WSSV322 revealed that both of the binding proteins had anti-apoptotic activity. However, using the same Sf-9 protocol with anti-apoptosis protein-1 (AAP-1; also called WSSV449) previously shown to bind and inactivate a different effector caspase from P.monodon ( Pm caspase) did not block apoptosis induced by PmCasp. The results revealed diversity in effector caspases and their viral protein inhibitors in P.monodon. © 2014 Elsevier Ltd.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-84896367759&doi=10.1016%2fj.fsi.2014.02.022&partnerID=40&md5=fadc8c3fc9d93f682d32b354dd09fe62
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): White spot syndrome virus 1
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
หากไม่พบเอกสารฉบับเต็ม (Full Text) โปรดติดต่อหน่วยงานเจ้าของข้อมูล

การอ้างอิง


TARR Wordcloud:
Two new anti-apoptotic proteins of white spot syndrome virus that bind to an effector caspase (PmCasp) of the giant tiger shrimp Penaeus (Penaeus) monodon
Lertwimol T.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
Identification and expression of white spot syndrome virus-encoded microRNAs in infected Penaeus monodon Needle biopsy of the hepatopancreas of the black tiger shrimp Penaeus monodon with Penaeus monodon densovirus detection Testing of a pond-side molecular diagnostic tool for the detection of white spot syndrome virus in shrimp aquaculture Yeast surface display of two proteins previously shown to be protective against white spot syndrome virus (WSSV) in shrimp Evidence that the whiteleg shrimp Penaeus (Litopenaeus) vannamei is refractory to infection by Penaeus monodon nudivirus (PmNV), also known as MBV Optimisation of electroporation and lipofection protocols to derive the black tiger shrimp cell line (Penaeus monodon) Delivery of double stranded RNA by Macrobrachium rosenbergii nodavirus-like particles to protect shrimp from white spot syndrome virus Alteration of egg activation by protease inhibitors in the black tiger shrimp, Penaeus monodon Yellow head virus binding to cell surface proteins from Penaeus monodon hemocytes A novel function of bursicon in stimulation of vitellogenin expression in black tiger shrimp, Penaeus monodon
คัดลอก URL
กระทู้ของฉัน
ผลการสืบค้นทั้งหมด โพสต์     เรียงลำดับจาก