สืบค้นงานวิจัย
Enhancement of TNF-α induced antiproliferation in human cervical cancer cells by extracts from Thai medicinal plants
Managit C. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Enhancement of TNF-α induced antiproliferation in human cervical cancer cells by extracts from Thai medicinal plants
ผู้แต่ง / หัวหน้าโครงการ (EN): Managit C.
บทคัดย่อ (EN): Human cervical cancer is known to be a dreadful disease with high resistance to chemotherapeutic drugs in clinical use. Natural products are valuable sources for development of anticancer agents. Many plant-derived anticancer compounds were reported to modulate signal transduction pathway associated with cell proliferation and apoptosis. One well-known pathway is via the enhancement of TNF-α, a cytokine that can induce apoptotic cell death and inhibit tumorigenesis. The purpose of this study is to evaluate TNF-α antiproliferative synergistic activity of Thai medicinal plant extracts. The antiproliferative effects were determined in human cervical cancer (HeLa) cells using WST-1 cell proliferating assay. Among twenty six different tested extracts at the concentration of 30 μg ml-1, 95% ethanolic extract from stems of Derris scandens, aqueous extract from leaves of Azadirachta indica, aqueous extract from leaves of A. indica var. siamensis and 95% ethanolic extract from roots of Amomum biflorum significantly decreased viability of HeLa cells treated with TNF-α (20 ng/ml). However, only 95% ethanolic extract from roots of A. biflorum combined with TNF-α significantly decreased viability of HeLa cells to 70.96±2.25% cell viability, when compared to cell viability of HeLa cells treated with only plant extract (93.84±10.73%). Data suggested that this plant extract enhanced TNF-α antiproliferative activity in HeLa cells and it has potential for further development as chemotherapeutic agent for anticancer therapy via the enhancement of TNF-α induced apoptosis of cancer cells. © ISHS.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899560993&partnerID=40&md5=c66ba2d81ba8a3ece00ba3f669bbe8d8
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): WST-1 cell proliferating assay
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
หากไม่พบเอกสารฉบับเต็ม (Full Text) โปรดติดต่อหน่วยงานเจ้าของข้อมูล

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Managit C.. "Enhancement of TNF-α induced antiproliferation in human cervical cancer cells by extracts from Thai medicinal plants". ไม่ระบุหน่วยงาน. ม.ป.ป.

Managit C.. "Enhancement of TNF-α induced antiproliferation in human cervical cancer cells by extracts from Thai medicinal plants". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



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Enhancement of TNF-α induced antiproliferation in human cervical cancer cells by extracts from Thai medicinal plants
Managit C.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
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