สืบค้นงานวิจัย
Antioxidant and Anti-Inflammatory Effects of Defatted Rice Bran (Oryza Sativa L.) Protein Hydrolysates on Raw 264.7 Macrophage Cells
Saisavoey T. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Antioxidant and Anti-Inflammatory Effects of Defatted Rice Bran (Oryza Sativa L.) Protein Hydrolysates on Raw 264.7 Macrophage Cells
ผู้แต่ง / หัวหน้าโครงการ (EN): Saisavoey T.
บทคัดย่อ (EN): Defatted rice bran (DRB) is a by-product of oil extraction from rice bran (Oryza sativa L.), and has health benefits. This in vitro study investigated the antioxidant and anti-inflammatory effects of four crude DRB protein hydrolysate fractions prepared by pepsin-pancreatin digestion and fractionated by ultrafiltration on a transformed macrophage cell line, RAW264.7. Protein hydrolysates with MW <3 kDa (F4 fraction) had the lowest IC50 for NO-, DPPH˙ and ABTS radical scavenging activities (0.38 ± 0.01, 1.24 ± 0.03 and 0.17 ± 0.01 µg/mL, respectively). The pooled fraction formed after Reverse phase-High-performance liquid chromatography (HPLC) (F4-5) had the highest percentage inhibition of radical scavenging for DPPH˙, and NO- (25.04 ± 0.88, and 6.50 ± 0.39%, respectively). LC-MS of F4-5 revealed peptides exhibiting antioxidant activity were composed of His (H), Trp (W) and Tyr (Y) that known to enhance the scavenging activities of peptides. The F4 fraction suppressed lipopolysaccharide and rmIFN-γ mediated increase in iNOS, IL-6 and TNF-α mRNA levels in RAW264.7 cells, suggesting the interference was mediated at the transcriptional level. Practical Application: Defatted rice bran (DRB) is a good source of nutritional proteins. In this study, DRB protein was hydrolyzed using proteases and further fractionated by ultrafiltration. The results demonstrated that DRB hydrolysates and their fractions exhibited antioxidant and anti-inflammatory activities indicating these as a potential source of functional food and medicines. © 2016 Wiley Periodicals, Inc.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-84960366391&doi=10.1111%2fjfbc.12266&partnerID=40&md5=8dfea5f1bf8ad735e92c8c1056b5201b
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Antioxidants
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
หากไม่พบเอกสารฉบับเต็ม (Full Text) โปรดติดต่อหน่วยงานเจ้าของข้อมูล

การอ้างอิง

Saisavoey T.. "Antioxidant and Anti-Inflammatory Effects of Defatted Rice Bran (Oryza Sativa L.) Protein Hydrolysates on Raw 264.7 Macrophage Cells". ไม่ระบุหน่วยงาน. ม.ป.ป.

Saisavoey T.. "Antioxidant and Anti-Inflammatory Effects of Defatted Rice Bran (Oryza Sativa L.) Protein Hydrolysates on Raw 264.7 Macrophage Cells". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



TARR Wordcloud:
Antioxidant and Anti-Inflammatory Effects of Defatted Rice Bran (Oryza Sativa L.) Protein Hydrolysates on Raw 264.7 Macrophage Cells
Saisavoey T.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
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