สืบค้นงานวิจัย
Anti-inflammatory and anti-insulin resistance activities of aqueous extract from Anoectochilus burmannicus
Budluang P. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Anti-inflammatory and anti-insulin resistance activities of aqueous extract from Anoectochilus burmannicus
ผู้แต่ง / หัวหน้าโครงการ (EN): Budluang P.
บทคัดย่อ (EN): This study investigated biological activities including antioxidative stress, anti-inflammation, and anti-insulin resistance of Anoectochilus burmannicus aqueous extract (ABE). The results showed abilities of ABE to scavenging DPPH and ABTS free radicals in a dose-dependent manner. Besides, ABE significantly reduced nitric oxide (NO) production in the lipopolysaccharide (LPS)-treated RAW 264.7 via inhibition of mRNA and protein expressions of nitric oxide synthase (iNOS). The LPS-induced mRNA expressions of cyclooxygenase-2 (COX-2) and interleukin 1β (IL-1β) were suppressed by ABE. Moreover, ABE exerted anti-insulin resistance activity as it significantly improved the glucose uptake in tumor necrosis factor (TNF)-α treated 3T3-L1 adipocytes. In addition, ABE at the concentration of up to 200 μg/mL was not toxic to human peripheral blood mononuclear cells (PBMCs) and did not induce mutations. Finally, the results of our study suggest the potential use of A. burmannicus as anti-inflammatory, anti-insulin resistance agents, or food supplement for prevention of chronic diseases. © 2016 The Authors. Food Science & Nutrition published by Wiley Periodicals, Inc.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-84997785114&doi=10.1002%2ffsn3.416&partnerID=40&md5=e982fa2072b91b2effc7d78c0e6d4ecd
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): RAW264.7 macrophage
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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Anti-inflammatory and anti-insulin resistance activities of aqueous extract from Anoectochilus burmannicus
Budluang P.
มหาวิทยาลัยมหิดล
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