คลังข้อมูลการวิจัยการเกษตรไทย

ผู้แต่ง Tiwaporn Nualkaew

เผยแพร่โดย

1 Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University, 25/25 Phuttamonthon 4 Road, Salaya, Nakhon Pathom, 73170, Thailand 2 Department of Forensic Science, Faculty of Allied Health Sciences, Thammasat University, Pathum Thani, Thailand 3 Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand 4 Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand 5 National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand 6 Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA 7 Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University, 25/25 Phuttamonthon 4 Road, Salaya, Nakhon Pathom, 73170, Thailand

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งานวิจัยที่แนะนำ Histone modification levels in β-thalassemia/hemoglobin E erythroid cells High-level induction of fetal haemoglobin by pomalidomide in β-thalassaemia/HbE erythroid progenitor cells Downregulation of transcription factor LRF/ZBTB7A increases fetal hemoglobin expression in -thalassemia/hemoglobin E erythroid cells Comparison of gene expression profiles between human erythroid cells derived from fetal liver and adult peripheral blood Cloning and expression of HbACO2 of Hevea brasiliensis Development of fetal hemoglobin inducers from medicinal plants for the clinical management of beta-thalassemia Cloning and expression of 3-hydroxy-3-methylglutaryl-Coa Reductase 1 (Hmge 1) from Hevea brasiliensis Qualitative and quantitative comparison of the proteome of erythroid cells differentiated from human iPSCs and adult erythroid cells by multiplex TMT labelling and nanoLC-MS/MS Decreased nitrite reductase activity of deoxyhemoglobin correlates with platelet activation in hemoglobin E/ß-thalassemia subjects Colloidal quantum dot ligand engineering for high performance solar cells

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ชื่อเรื่อง (EN):	UNC0638 induces high levels of fetal hemoglobin expression in β-thalassemia/HbE erythroid progenitor cells
ผู้แต่ง / หัวหน้าโครงการ (EN):	Tiwaporn Nualkaew
บทคัดย่อ (EN):	Increased expression of fetal hemoglobin (HbF) improves the clinical severity of β-thalassemia patients. EHMT1/2 histone methyltransferases are epigenetic modifying enzymes that are responsible for catalyzing addition of the repressive histone mark H3K9me2 at silenced genes, including the g-globin genes. UNC0638, a chemical inhibitor of EHMT1/2, has been shown to induce HbF expression in human erythroid progenitor cell cultures. Here, we report the HbF-inducing activity of UNC0638 in erythroid progenitor cells from β-thalassemia/HbE patients. UNC0638 treatment led to significant increases in g-globin mRNA, HbF expression, and HbF-containing cells in the absence of significant cytotoxicity. Moreover, UNC0638 showed additive effects on HbF induction in combination with the immunomodulatory drug pomalidomide and the DNMT1 inhibitor decitabine. These studies provide a scientific proof of concept that a small molecule targeting EHMT1/2 epigenetic enzymes, used alone or in combination with pomalidomide or decitabine, is a potential therapeutic approach for HbF induction. Further development of structural analogs of UNC0638 with similar biological effects but improved pharmacokinetic properties may lead to promising therapies and possible clinical application for the treatment of β-thalassemia.
บทคัดย่อ:	ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN):	en
เอกสารแนบ (EN):	http://nih.dmsc.moph.go.th/research/showimgdetil.php?id=581
เผยแพร่โดย (EN):	1 Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University, 25/25 Phuttamonthon 4 Road, Salaya, Nakhon Pathom, 73170, Thailand 2 Department of Forensic Science, Faculty of Allied Health Sciences, Thammasat University, Pathum Thani, Thailand 3 Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand 4 Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand 5 National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand 6 Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA 7 Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University, 25/25 Phuttamonthon 4 Road, Salaya, Nakhon Pathom, 73170, Thailand
คำสำคัญ (EN):	Decitabine
เจ้าของลิขสิทธิ์ (EN):	National Institute of Health, Department of Medical Science