สืบค้นงานวิจัย
Cadmium induces apoptotic program imbalance and cell cycle inhibitor expression in cultured human astrocytes
Ospondpant D. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Cadmium induces apoptotic program imbalance and cell cycle inhibitor expression in cultured human astrocytes
ผู้แต่ง / หัวหน้าโครงการ (EN): Ospondpant D.
บทคัดย่อ (EN): Cadmium is a highly neurotoxic heavy metal impairing neurogenesis and induces neurodegenerative disorders. Toxic concentrations of cadmium induce astrocytic apoptosis by depleting intracellular glutathione levels, elevating intracellular calcium levels, altering mitochondria membrane potentials, and activating JNK and PI3K/Akt signaling pathways. Cadmium suppresses cell proliferation in kidney epithelial cells, lung fibroblasts, and primary myelocytes; however, cadmium's effects on proteins regulating oxidative stress, apoptosis, and cell proliferation in astrocytes are less known. The present study hypothesized that cadmium alters levels of antioxidant enzymes, apoptotic regulator proteins, and cell cycle inhibitor proteins, resulting in apoptosis and cell cycle arrest. Concentrations ≥20 μM cadmium induced apoptosis and led to intracellular changes including DNA fragmentation, reduced mRNA expression of antioxidant enzymes (i.e., catalase and glutathione S transferase-A4), downregulation of B-cell lymphoma 2 (Bcl-2), and upregulation of Bcl-2-associated X protein (Bax). Moreover, cadmium suppressed astrocytic proliferation by inducing S and G2/M phase cell cycle arrest and promoting p53, p21, and p27 expression. In conclusion, this study provides mechanistic insight into cadmium-induced cytotoxicity of astrocytes and highlights potential targets for prevention of cadmium-induced apoptosis and cell cycle arrest. © 2018 Elsevier B.V.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-85057734636&doi=10.1016%2fj.etap.2018.12.001&partnerID=40&md5=7072fbe003138692cf27f1fd6e28ad76
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Tumor Suppressor Proteins
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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Ospondpant D.. "Cadmium induces apoptotic program imbalance and cell cycle inhibitor expression in cultured human astrocytes". ไม่ระบุหน่วยงาน. ม.ป.ป.

Ospondpant D.. "Cadmium induces apoptotic program imbalance and cell cycle inhibitor expression in cultured human astrocytes". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



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Cadmium induces apoptotic program imbalance and cell cycle inhibitor expression in cultured human astrocytes
Ospondpant D.
มหาวิทยาลัยมหิดล
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