สืบค้นงานวิจัย
Effects of extracts from thai piperaceae plants against infection with toxoplasma gondii
Leesombun A. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Effects of extracts from thai piperaceae plants against infection with toxoplasma gondii
ผู้แต่ง / หัวหน้าโครงการ (EN): Leesombun A.
บทคัดย่อ (EN): Herbal medicines and natural herb extracts are widely used as alternative treatments for various parasitic diseases, and such extracts may also have potential to decrease the side effects of the standard regimen drugs used to treat toxoplasmosis (sulfadiazine-pyrimethamine combination). We evaluated how effective the Thai piperaceae plants Piper betle, P. nigrum and P. sarmentosum are against Toxoplasma gondii infection in vitro and in vivo. Individually, we extracted the piperaceae plants with ethanol, passed them through a rotary evaporator and then lyophilized them to obtain crude extracts for each one. The in vitro study indicated that the P. betle extract was the most effective extract at inhibiting parasite growth in HFF cells (IC50 on RH-GFP: 23.2 μg/mL, IC50 on PLK-GFP: 21.4 μg/mL). Furthermore, treatment of experimental mice with the P. betle extract for 7 days after infection with 1,000 tachyzoites of the T. gondii PLK strain increased their survival (survival rates: 100% in 400 mg/kg-treated, 83.3% in 100 mg/kg-treated, 33.3% in 25 mg/kg-treated, 33.3% in untreated mice). Furthermore, treatment with 400 mg/kg of the P. betle extract resulted in 100% mouse survival following infection with 100,000 tachyzoites. The present study shows that P. betle extract has the potential to act as a medical plant for the treatment of toxoplasmosis. © 2016 Leesombun et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-84971003305&doi=10.1371%2fjournal.pone.0156116&partnerID=40&md5=422ba92ef72529b855b33b543e1898b8
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Vero Cells
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
หากไม่พบเอกสารฉบับเต็ม (Full Text) โปรดติดต่อหน่วยงานเจ้าของข้อมูล

การอ้างอิง

Leesombun A.. "Effects of extracts from thai piperaceae plants against infection with toxoplasma gondii". ไม่ระบุหน่วยงาน. ม.ป.ป.

Leesombun A.. "Effects of extracts from thai piperaceae plants against infection with toxoplasma gondii". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



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Effects of extracts from thai piperaceae plants against infection with toxoplasma gondii
Leesombun A.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
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