สืบค้นงานวิจัย
Estimating the impact of expanding treatment coverage and allocation strategies for chronic hepatitis c in a direct antiviral agent era
Poovorawan K. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Estimating the impact of expanding treatment coverage and allocation strategies for chronic hepatitis c in a direct antiviral agent era
ผู้แต่ง / หัวหน้าโครงการ (EN): Poovorawan K.
บทคัดย่อ (EN): Hepatitis C virus (HCV) infection is an important worldwide public health problem, and most of the global HCV burden is in low-to middle-income countries. This study aimed to estimate the future burden of chronic hepatitis C (CHC) and the impact of public health policies using novel antiviral agents in Thailand. A mathematical model of CHC transmission dynamics was constructed to examine the disease burden over the next 20 years using different treatment strategies. We compared and evaluated the current treatment (PEGylated interferon and ribavirin) with new treatments using novel direct-Acting antiviral agents among various treatment policies. Thailand's CHC prevalence was estimated to decrease 1.09%-0.19% in 2015-2035. Expanding treatment coverage (i.e., a five-fold increment in treatment accessibility) was estimated to decrease cumulative deaths (33,007 deaths avoided, 25.5% reduction) from CHC-related decompensated cirrhosis and hepatocellular carcinoma (HCC). The yearly incidence of HCC-Associated HCV was estimated to decrease from 2,305 to 1,877 cases yearly with expanding treatment coverage. A generalized treatment scenario (i.e., an equal proportional distribution of available treatment to individuals at all disease stages according to the number of cases at each stage) was predicted to further reduce death from HCC (9,170 deaths avoided, 11.3% reduction) and the annual incidence of HCC (i.e., a further decrease from 1,877 to 1,168 cases yearly, 37.7% reduction), but cumulative deaths were predicted to increase (by 3,626 deaths, 3.7% increase). Based on the extensive coverage scenario and the generalized treatment scenario, we estimated near-zero death from decompensated cirrhosis in 2031. In conclusion, CHC-related morbidity and mortality in Thailand are estimated to decrease dramatically over the next 20years. Treatment coverage and allocation strategies are important factors that affect the future burden of CHC in resource-limited countries like Thailand. © 2016 Poovorawan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-84992418561&doi=10.1371%2fjournal.pone.0163095&partnerID=40&md5=8c04fde2ae4c8329f768b1bde321e290
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Prevalence
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
หากไม่พบเอกสารฉบับเต็ม (Full Text) โปรดติดต่อหน่วยงานเจ้าของข้อมูล

การอ้างอิง

Poovorawan K.. "Estimating the impact of expanding treatment coverage and allocation strategies for chronic hepatitis c in a direct antiviral agent era". ไม่ระบุหน่วยงาน. ม.ป.ป.

Poovorawan K.. "Estimating the impact of expanding treatment coverage and allocation strategies for chronic hepatitis c in a direct antiviral agent era". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



TARR Wordcloud:
Estimating the impact of expanding treatment coverage and allocation strategies for chronic hepatitis c in a direct antiviral agent era
Poovorawan K.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
Efficacy of second generation direct-acting antiviral agents for treatment naïve hepatitis C genotype 1: A systematic review and network meta-analysis Swine is a possible source of hepatitis E virus infection by comparative study of hepatitis A and E seroprevalence in Thailand Liver disease burden and required treatment expenditures for hepatitis C virus (HCV) infection in Thailand: Implications for HCV elimination in the new therapeutic era, a population-based study An Outbreak of Acute Hepatitis Caused by Genotype IB Hepatitis A Viruses Contaminating the Water Supply in Thailand Lateral ear canal resection for the treatment of chronic otorrhoea in buffaloes (Buffalo Bulletin,40(1)) Association of Sjögrens syndrome in patients with chronic hepatitis virus infection: A population-based analysis Evaluation of removal efficiency of human antibiotics in wastewater treatment plants in Bangkok, Thailand PERFORMANCE OF TREATMENT OF RUBBER PROCESS EFFLUENTS BY ANAEROBIC – AEROBIC TREATMENT PLANTS IN SRI LANKA Occurrence and efficacy of bisphenol A (BPA) treatment in selected municipalwastewater treatment plants, Bangkok, Thailand Treatment cost and costing model of obstetric complications at a hospital in Myanmar
คัดลอก URL
กระทู้ของฉัน
ผลการสืบค้นทั้งหมด โพสต์     เรียงลำดับจาก
พัฒนาระบบโดยศูนย์ความรู้เฉพาะด้านวิศวกรรมความรู้และวิศวกรรมภาษาDeveloped by Center of Excellence for Unified Knowledge and Language Engineering
สนับสนุนโดยสำนักงานพัฒนาการวิจัยการเกษตร (องค์การมหาชน)Supported by the Agricultural Research Development Agency (Public Organization)
แบบสำรวจความพึงพอใจQuestionair