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ผู้แต่ง National Institute of Health, Department of Medical Science

เผยแพร่โดย

1 Toxicology Center, National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi Province, Thailand. 2 Regional Medical Sciences Center 2, Department of Medical Sciences, Ministry of Public Health, Phitsanulok Province, Thailand

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งานวิจัยที่แนะนำ Thai Cosmetopoeia การขับเคลื่อนเศรษฐกิจสังคมไทยด้วยการสร้างสรรคุณค่าเครื่องสำอางตามเอกลักษณ์ท้องถิ่น Thai Open GLAM T‑SPOT®.TB Test for Latent Tuberculosis infection Diagnosis and Treatment Guidance in Thai Health‑Care Professionals Effect of pesticide exposure on immunological, hematological and biochemical parameters in thai orchid farmers— A cross-sectional study VDO แนะนำ สวทช. Thai Version (6:24 นาที) VDO แนะนำ สวทช. Thai Version สั้น (3:58 นาที) VDO แนะนำบริการ สำหรับภาคเอกชน Thai Version Serum concentrations of organochlorine pesticides p,p-DDE in adult Thai residents with background levels of exposure Copy number variation in Thai population Lifestyle behaviors and serum vitamin C in the thai population in Bangkok metropolitan

คัดลอก URL

ชื่อเรื่อง (EN):	Associations between urinary excretion of cadmium with alpha-1 microglobulin and microalbuminuria: a cross-sectional study in northwestern Thai population
ผู้แต่ง / หัวหน้าโครงการ (EN):	National Institute of Health, Department of Medical Science
บทคัดย่อ (EN):	Background: In Thailand, a high Cadmium (Cd) levels were observed in the northwestern population, especially in Mae Sot District, Tak Province. However, the association between urinary cadmium level and changes in renal biomarkers after long-term expose has not been studied, especially in case of low-level Cd exposures. Objectives: The main focus of this study was to investigate the associations between urinary cadmium levels and renal biomarkers in the northwestern Thai population. Materials and methods: A total of 817 persons (males=309, females=508) living in Cd-polluted area of Mae Sot district were participated in this study. The urinary cadmium level was analyzed using graphite furnace atomic absorption spectrometry (GFAAS). Two renal biochemical markers were selected, namely urinary alpha-1-microglobulin and microalbuminuria. Results and Conclusion: The geometric mean concentration for urinary cadmium was 3.67(±3.08) μg/gm creatinine and 4.83(±3.82) μg/gm creatinine in adult males and females, respectively. Based on correlation analysis, the urinary cadmium level was positively correlated with age, years of residence, microalbuminuria and urinary alpha-1 microglobulin in both male and female. While a significant inverse correlation was found between the urinary cadmium level and BMI. Linear regression analysis yielded that alpha-1-microglobulin and microalbuminuria were significantly increased with increasing of urinary cadmium levels. Interestingly, the prevalence of increased alpha-1 microglobulin was higher than the prevalence of increased microalbuminuria in subjects with low urinary cadmium levels. The findings of this study indicate that urinary alpha-1 microglobulin showed a best of biomarker for monitoring the low-level of Cd exposure in both populations.
บทคัดย่อ:	ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN):	en
เอกสารแนบ (EN):	http://nih.dmsc.moph.go.th/research/showimgdetil.php?id=743
เผยแพร่โดย (EN):	1 Toxicology Center, National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi Province, Thailand. 2 Regional Medical Sciences Center 2, Department of Medical Sciences, Ministry of Public Health, Phitsanulok Province, Thailand
คำสำคัญ (EN):	Urinary cadmium
เจ้าของลิขสิทธิ์ (EN):	National Institute of Health, Department of Medical Science