สืบค้นงานวิจัย
Artemisinin-resistant Plasmodium falciparum malaria
Fairhurst R.M. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Artemisinin-resistant Plasmodium falciparum malaria
ผู้แต่ง / หัวหน้าโครงการ (EN): Fairhurst R.M.
บทคัดย่อ (EN): For more than five decades, Southeast Asia (SEA) has been fertile ground for the emergence of drug-resistant Plasmodium falciparum malaria. After generating parasites resistant to chloroquine, sulfadoxine, pyrimethamine, quinine, and mefloquine, this region has now spawned parasites resistant to artemisinins, the world's most potent antimalarial drugs. In areas where artemisinin resistance is prevalent, artemisinin combination therapies (ACTs)-the first-line treatments for malaria-are failing fast. This worrisome development threatens to make malaria practically untreatable in SEA, and threatens to compromise global endeavors to eliminate this disease. A recent series of clinical, in vitro, genomics, and transcriptomics studies in SEA have defined in vivo and in vitro phenotypes of artemisinin resistance, identified its causal genetic determinant, explored its molecular mechanism, and assessed its clinical impact. Specifically, these studies have established that artemisinin resistance manifests as slow parasite clearance in patients and increased survival of early-ring-stage parasites in vitro; is caused by single nucleotide polymorphisms in the parasite's K13 gene, is associated with an upregulated "unfolded protein response" pathway that may antagonize the pro-oxidant activity of artemisinins, and selects for partner drug resistance that rapidly leads to ACT failures. In SEA, clinical studies are urgently needed to monitor ACT efficacy where K13 mutations are prevalent, test whether new combinations of currently available drugs cure ACT failures, and advance new antimalarial compounds through preclinical pipelines and into clinical trials. Intensifying these efforts should help to forestall the spread of artemisinin and partner drug resistance from SEA to sub-Saharan Africa, where the world's malaria transmission, morbidity, and mortality rates are highest. © 2016 American Society for Microbiology.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-85011275750&doi=10.1128%2fmicrobiolspec.EI10-0013-2016&partnerID=40&md5=89f765bddfcb01a17ecfd4e43df2d780
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Plasmodium falciparum
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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Fairhurst R.M.. "Artemisinin-resistant Plasmodium falciparum malaria". ไม่ระบุหน่วยงาน. ม.ป.ป.

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Artemisinin-resistant Plasmodium falciparum malaria
Fairhurst R.M.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
Longitudinal genomic surveillance of Plasmodium falciparum malaria parasites reveals complex genomic architecture of emerging artemisinin resistance Plasmodium falciparum field isolates from areas of repeated emergence of drug resistant malaria show no evidence of hypermutator phenotype Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance Quantifying connectivity between local Plasmodium falciparum malaria parasite populations using identity by descent Genetic diversity of plasmodium falciparum populations in malaria declining areas of Sabah, East Malaysia Inhibition of merozoite invasion and transient de-sequestration by sevuparin in humans with Plasmodium falciparum malaria Sequence variation in Plasmodium falciparum merozoite surface protein-2 is associated with virulence causing severe and cerebral malaria IgE low affinity receptor (CD23) expression, Plasmodium falciparum specific IgE and tumor necrosis factor-alpha production in Thai uncomplicated and severe falciparum malaria patients Prevalence of Plasmodium falciparum molecular markers of antimalarial drug resistance in a residual malaria focus area in Sabah, Malaysia Origin of robustness in generating drug-resistant malaria parasites
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