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Intrinsic toxicity of stable nanosized titanium dioxide using polyacrylate in human keratinocytes
Koedrith P. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Intrinsic toxicity of stable nanosized titanium dioxide using polyacrylate in human keratinocytes
ผู้แต่ง / หัวหน้าโครงการ (EN): Koedrith P.
บทคัดย่อ (EN): s: Trends in the use of an anticoagulant as a dispersing stabilizer are addressed. An effective approach to preparing stable nanosized titanium dioxide (nTiO 2 ) for accurate and systematic assessment of nano- toxicity has not been established. Methods: Among the dispersants tested here, it was found that sodium polyacrylate (PAA) was the most effective dispersant for nTiO 2 in culture media. Our study was the first to demonstrate that a stable PAA-dispersed nTiO 2 (nTiO 2 /PAA) suspension showed more toxic than nTiO 2 without PAA in human HaCaT keratinocytes. Results: Initially, MTT results showed that the stable nTiO 2 /PAA dispersion exhibited significantly greater cytotoxicity than nTiO 2 without PAA. In addition, the stable nTiO 2 /PAA dispersion induced markedly more oxidative stress than nTiO 2 without PAA. Importantly, the stable nTiO 2 /PAA dispersion caused DNA breakage to a greater extent than nTiO 2 without PAA. Conclusion: Our findings indicated that the anti-coagulant PAA is suitable for preparing homologous dispersed nTiO 2 under realistic physiological culture test conditions. © 2018, The Korean Society of Toxicogenomics and Toxicoproteomics and Springer Nature B.V.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-85060332500&doi=10.1007%2fs13273-018-0030-4&partnerID=40&md5=f7338df34cf308d3df3111214fc4fac9
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): skin toxicity
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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Intrinsic toxicity of stable nanosized titanium dioxide using polyacrylate in human keratinocytes
Koedrith P.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
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