คลังข้อมูลการวิจัยการเกษตรไทย

ผู้แต่ง Supathra Tiewcharoen

เผยแพร่โดย

1 Department of Parasitology, 2 Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 3 Department of Biology, Faculty of Science, Silpakorn University, Nakhon Pathom; 4 Genome Institute, National Center for Genetic Engineering and Biotechnology, Pathum Thani; 5 National Institute of Health, Department of Medical Sciences, Nonthaburi; 6 Center of Nanoimaging, Faculty of Science, Mahidol University, Bangkok, Thailand

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หน่วยงาน ไม่ระบุหน่วยงาน

งานวิจัยที่แนะนำ Prevalence and antimicrobial susceptibility of Campylobacter isolated from retail chickens in Thailand Prevalence and antimicrobial susceptibility of Campylobacter spp. isolated from clinical samples during 2012-2015 Prevalence and antimicrobial resistance of Campylobacter spp. isolated from retail chicken products in central Thailand Development of a rapid, simple method for detecting Naegleria fowleri visually in water samples by Loop-Mediated Isothermal Amplification (LAMP) Ultra Structure changes of diosgenin-treated human monocyte U937-derived macrophages induced by naegleria fowleri lysate Characterization of an abalone gonadotropin-releasing hormone and its effect on ovarian cell proliferation Indian Synthetic Rubber Industry – Prospective Effect of Stemona spp. against Rhipicephalus microplus EFFECT OF SILT PITS ON MATURE RUBBER PLANTATION Antifertility effect of Bougainvillea spectabilis or paper flower

คัดลอก URL

ชื่อเรื่อง (EN):	Effect of synthetic antimicrobial peptides on Naegleria fowleri trophozoites
ผู้แต่ง / หัวหน้าโครงการ (EN):	Supathra Tiewcharoen
บทคัดย่อ (EN):	We evaluated the effect of tritrpticin, lactoferrin, killer decapeptide and scrambled peptide in vitro against Naegleria fowleri trophozoites compared with amphotericin B. Tritrpticin (100 µg/ml) caused apoptosis of N. fowleri trophozoites (2x105 cells/ml), while lactoferrin, killer decapeptide and scrambled peptide did not. On Gormori trichrome staining, tritrpticin affected the elasticity of the surface membrane and reduced the size of the nuclei of N. fowleri trophozoites. The ultrastructure surface membrane and food cup formation of the trophozoites were 100% inhibited. These results are consistent with inhibition of the nfa1, Mp2CL5 of the treated trophozoite, which plays a role in food cup formation. Tritrpticin 100 µg/ml was not toxic against SK-N-MC cells. Our findings suggest tritrpticin has activity against the surface membrane and nfa1and Mp2CL5 of N. fowleri trophozoites and could be developed as a potential therapeutic agent.
บทคัดย่อ:	ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN):	en
เอกสารแนบ (EN):	http://nih.dmsc.moph.go.th/research/showimgdetil.php?id=453
เผยแพร่โดย (EN):	1 Department of Parasitology, 2 Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 3 Department of Biology, Faculty of Science, Silpakorn University, Nakhon Pathom; 4 Genome Institute, National Center for Genetic Engineering and Biotechnology, Pathum Thani; 5 National Institute of Health, Department of Medical Sciences, Nonthaburi; 6 Center of Nanoimaging, Faculty of Science, Mahidol University, Bangkok, Thailand
คำสำคัญ (EN):	Effect of synthetic antimicrobial peptides
เจ้าของลิขสิทธิ์ (EN):	National Institute of Health, Department of Medical Science