สืบค้นงานวิจัย
Cytokine-induced killer cells: A novel treatment for allergic airway inflammation
Pluangnooch P. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Cytokine-induced killer cells: A novel treatment for allergic airway inflammation
ผู้แต่ง / หัวหน้าโครงการ (EN): Pluangnooch P.
บทคัดย่อ (EN): The effectiveness of cytokine-induced killer (CIK) cells for treatment of cancers has long been appreciated. Here, we report for the first time that CIK cells can be applied to treat allergic airway inflammation. Adopting from an established protocol with some modifications, we generated CIK cells ex vivo from mouse T cells, and examined their effectiveness in treatment of allergic airway inflammation using the ovalbumin-induced model of allergic airway inflammation. Based upon evaluation of bronchoalveolar lavage cellularity, T helper type2 cytokine levels and lung histology, all of which are important parameters for determining the severity of allergic airway inflammation, diseased mice treated with CIK cells showed significant reductions in all the parameters without any obvious adverse effects. Interestingly, the observed effects were comparable to those treated with dexamethasone. Thus, our study provides a novel application of CIK cells in treatment of allergic airway inflammation. © 2017 Pluangnooch et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-85032447316&doi=10.1371%2fjournal.pone.0186971&partnerID=40&md5=92b24605fdf37ccceb2d5141fdd0b30a
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Th1 Cells
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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Cytokine-induced killer cells: A novel treatment for allergic airway inflammation
Pluangnooch P.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
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