คลังข้อมูลการวิจัยการเกษตรไทย

ผู้แต่ง Khawcharoenporn

เผยแพร่โดย

1 Division of Infectious Diseases, Faculty of Medicine, Thammasat University. 2 National Institute of Health, Department of Medical Sciences, Ministry of Public Health.

เผยแพร่เมื่อ ไม่ระบุวันที่เผยแพร่

หน่วยงาน ไม่ระบุหน่วยงาน

งานวิจัยที่แนะนำ Tuberculin skin test and QuantiFERON-TB Gold In-tube Test for latent tuberculosis in Thai HIV-infected adults QuantiFERON-TB Gold In-Tube test in active tuberculosis patients and healthy adults Method verification of Isolated Chicken Eye Test QuanFERON®-TB GOLD in-tUBE test for diagnosing latent tuberculosis infection among clinical-year Thai medical students Tuberculin skin test and QuantiFERON®-TB Gold In-tube Test for diagnosing latent tuberculosis infection among Thai healthcare workers T-SPOT.TB test and clinical risk scoring for diagnosis of latent tuberculosis infection among Thai healthcare workers T-SPOT®.TB test and clinical risk scoring for diagnosis of latent tuberculosis infection among Thai healthcare workers. T-SPOT.TB test ในการตรวจวินิจฉัยการติดเชื้อวัณโรคและติดตามการรักษาแบบป้องกันในกลุ่มบุคลากรทางการแพทย์ T-SPOT.TB test for detecting Mycobacterium tuberculosis infection and monitoring the prophylactic Efficacy Evaluation Test 15min Prevalence of HIV infection, access to HIV care, and response to antiretroviral therapy among partners of HIV-infected individuals in Thailand

คัดลอก URL

ชื่อเรื่อง (EN):	QuantiFERON-TB Gold In-Tube Test for Tuberculosis Prevention in HIV-Infected Patients
ผู้แต่ง / หัวหน้าโครงการ (EN):	Khawcharoenporn
บทคัดย่อ (EN):	Optimal testing strategies for diagnosing latent tuberculosis infection and the administration of isoniazid preventive therapy (IPT) remain uncertain among human immunodeficiency virus (HIV)-infected patients. A 4-year prospective study was conducted among Thai HIV-infected patients who underwent simultaneous tuberculin skin test (TST) and QuantiFERON-TB Gold In-Tube Test (QFT-IT) at care entry. Based on baseline test results, patients were categorized into the following 4 groups: i) QFT-IT-positive, TST-reactive; ii) QFT-IT-positive, TST-non-reactive; iii) QFT-IT-negative, TST-reactive; and iv) QFT-IT-negative, TST-non-reactive. The QFT-IT-positive patients were offered 9-month IPT and were QFT-IT tested annually. Of the 150 enrolled patients, 8, 12, 16, and 114 patients were assigned to groups 1, 2, 3, and 4, respectively. Sixteen of 19 QFT-IT-positive patients (84%) completed IPT. The incidence of tuberculosis was significantly higher in patients who declined IPT than in those underwent treatment (11.11 vs. 0 case/100 patient-year; P < 0.001). Among the 16 patients completing IPT, 11 (69%) and 2 (12%) had QFT-IT reversion at 1 and 2 years after IPT, respectively. The remaining 3 (19%) did not demonstrate any reversion, and their baseline interferon-y (IFN-y) levels were above 1.2 IU/mL. Initial QFT-IT-guided IPT was effective in preventing tuberculosis. Serial QFT-IT for evaluating IPT effectiveness had limitations because of delayed or lack of reversion, especially for patients with high baseline IFN-y levels.
บทคัดย่อ:	ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN):	en
เอกสารแนบ (EN):	http://nih.dmsc.moph.go.th/research/showimgdetil.php?id=503
เผยแพร่โดย (EN):	1 Division of Infectious Diseases, Faculty of Medicine, Thammasat University. 2 National Institute of Health, Department of Medical Sciences, Ministry of Public Health.
คำสำคัญ (EN):	QuantiFERON-TB Gold In-Tube Test; Thailand; human immunodeficiency virus; isoniazid preventive therapy (IPT); latent tuberculosis infection
เจ้าของลิขสิทธิ์ (EN):	National Institute of Health, Department of Medical Science