สืบค้นงานวิจัย
Diversifying selection on the thrombospondin-related adhesive protein (TRAP) gene of plasmodium falciparum in Thailand
Ohashi J. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Diversifying selection on the thrombospondin-related adhesive protein (TRAP) gene of plasmodium falciparum in Thailand
ผู้แต่ง / หัวหน้าโครงการ (EN): Ohashi J.
บทคัดย่อ (EN): Sporozoites of Plasmodium falciparum are transmitted to human hosts by Anopheles mosquitoes. Thrombospondin-related adhesive protein (TRAP) is expressed in sporozoites and plays a crucial role in sporozoite gliding and invasion of human hepatocytes. A previous study showed that the TRAP gene has been subjected to balancing selection in the Gambian P. falciparum population. To further study the molecular evolution of the TRAP gene in Plasmodium falciparum, we investigated TRAP polymorphisms in P. falciparum isolates from Suan Phueng District in Ratchaburi Province, Thailand. The analysis of the entire TRAP coding sequences in 32 isolates identified a total of 39 single nucleotide polymorphisms (SNPs), which comprised 37 nonsynonymous and two synonymous SNPs. McDonald-Kreitman test showed that the ratio of the number of nonsynonymous to synonymous polymorphic sites within P. falciparum was significantly higher than that of the number of nonsynonymous to synonymous fixed sites between P. falciparum and P. reichenowi. Furthermore, the rate of nonsynonymous substitution was significantly higher than that of synonymous substitution within Thai P. falciparum. These results indicate that the TRAP gene has been subject to diversifying selection in the Thai P. falciparum population as well as the Gambian P. falciparum population. Comparison of our P. falciparum isolates with those from another region of Thailand (Tak province, Thailand) revealed that TRAP was highly differentiated between geographically close regions. This rapid diversification seems to reflect strong recent positive selection on TRAP. Our results suggest that the TRAP molecule is a major target of the human immune response to pre-erythrocytic stages of P. falciparum. © 2014 Ohashi et al. This.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-84896508042&doi=10.1371%2fjournal.pone.0090522&partnerID=40&md5=fa1a5ce8ae21b256eaf5947c5c84e293
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Thailand
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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การอ้างอิง

Ohashi J.. "Diversifying selection on the thrombospondin-related adhesive protein (TRAP) gene of plasmodium falciparum in Thailand". ไม่ระบุหน่วยงาน. ม.ป.ป.

Ohashi J.. "Diversifying selection on the thrombospondin-related adhesive protein (TRAP) gene of plasmodium falciparum in Thailand". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



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Diversifying selection on the thrombospondin-related adhesive protein (TRAP) gene of plasmodium falciparum in Thailand
Ohashi J.
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