คลังข้อมูลการวิจัยการเกษตรไทย

ผู้แต่ง Ratana Tacharoenmuang

เผยแพร่โดย

1 National Institute of Health, Department of Medical Sciences, Nonthaburi 11000, Thailand 2 Department of Virology and Parasitology, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan. 3 Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan 4 Medical Sciences Technical Office, Department of Medical Sciences, Nonthaburi 11000, Thailand. 5 Thailand-Japan Research Collaboration Center on Emerging and Re-Emerging Infections, Nonthaburi 11000, Thailand 6 Osaka Institute of Public Health, Osaka 537-0025, Japan.

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งานวิจัยที่แนะนำ Full genome characterization of novel DS-1-like G9P[8] rotavirus strains that have emerged in Thailand Full genomic analysis of a human G9P[23] rotavirus strain from a child with diarrhea in Thailand Whole Genomic Analysis of an Unusual Human G6P[14] Rotavirus Strain Isolated from a Child with Diarrhea in Thailand: Evidence for Bovine-To-Human Interspecies Transmission and Reassortment Events Norovirus transmission mediated by asymptomatic family members in households Characterization of a G10P[14] rotavirus strain from a diarrheic child in Thailand: Evidence for bovine-to-human zoonotic transmission Draft Genome Sequence of a Clostridium botulinum Isolate from Thailand Harboring the Subtype bont/B8 Gene Emergence and Characterization of Unusual DS-1-Like G1P[8] Rotavirus Strains in Children with Diarrhea in Thailand PESTICIDES USED IN THAILAND AND TOXIC EFFECTS TO HUMAN HEALTH Molecular Characterization of Clostridium botulinum Isolates from Foodborne Outbreaks in Thailand, 2010 Full Genome Characterization of Novel DS-1-Like G8P[8] Rotavirus Strains that Have Emerged in Thailand: Reassortment of Bovine and Human Rotavirus Gene Segments in Emerging DS-1-Like Intergenogroup Re

คัดลอก URL

ชื่อเรื่อง (EN):	Full genome-based characterization of G4P[6] rotavirus strains from diarrheic patients in Thailand: Evidence for independent porcine-to-human interspecies transmission events
ผู้แต่ง / หัวหน้าโครงการ (EN):	Ratana Tacharoenmuang
บทคัดย่อ (EN):	The exact evolutionary patterns of human G4P[6] rotavirus strains remain to be elucidated. Such strains possess unique and strain-specific genotype constellations, raising the question of whether G4P[6] strains are primarily transmitted via independent interspecies transmission or human-to-human transmission after interspecies transmission. Two G4P[6] rotavirus strains were identified in fecal specimens from hospitalized patients with severe diarrhea in Thailand, namely, DU2014-259 (RVA/Human-wt/THA/DU2014-259/2014/G4P[6]) and PK2015-1-0001 (RVA/Human-wt/THA/PK2015-1-0001/2015/G4P[6]). Here, we analyzed the full genomes of the two human G4P[6] strains, which provided the opportunity to study and confirm their evolutionary origin. On whole genome analysis, both strains exhibited a unique Wa-like genotype constellation of G4-P[6]-I1-R1-C1-M1-A8-N1-T1-E1-H1. The NSP1 genotype A8 is commonly found in porcine rotavirus strains. Furthermore, on phylogenetic analysis, each of the 11 genes of strains DU2014-259 and PK2015-1-0001 appeared to be of porcine origin. On the other hand, the two study strains consistently formed distinct clusters for nine of the 11 gene segments (VP4, VP6, VP1-VP3, and NSP2-NSP5), strongly indicating the occurrence of independent porcine-to-human interspecies transmission events. Our observations provide important insights into the origin of zoonotic G4P[6] strains, and into the dynamic interaction between porcine and human rotavirus strains.
บทคัดย่อ:	ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN):	en
เอกสารแนบ (EN):	http://nih.dmsc.moph.go.th/research/showimgdetil.php?id=757
เผยแพร่โดย (EN):	1 National Institute of Health, Department of Medical Sciences, Nonthaburi 11000, Thailand 2 Department of Virology and Parasitology, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan. 3 Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan 4 Medical Sciences Technical Office, Department of Medical Sciences, Nonthaburi 11000, Thailand. 5 Thailand-Japan Research Collaboration Center on Emerging and Re-Emerging Infections, Nonthaburi 11000, Thailand 6 Osaka Institute of Public Health, Osaka 537-0025, Japan.
คำสำคัญ (EN):	Thailand
เจ้าของลิขสิทธิ์ (EN):	National Institute of Health, Department of Medical Science