สืบค้นงานวิจัย
Periods of high dengue transmission defined by rainfall do not impact efficacy of dengue vaccine in regions of endemic disease
Pasin C. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Periods of high dengue transmission defined by rainfall do not impact efficacy of dengue vaccine in regions of endemic disease
ผู้แต่ง / หัวหน้าโครงการ (EN): Pasin C.
บทคัดย่อ (EN): Objective To evaluate the association of rainy season with overall dengue disease incidence and with the efficacy of the Sanofi Pasteur recombinant, live, attenuated, tetravalent vaccine (CYDTDV) in two randomized, controlled multicenter phase III clinical trials in Asia and Latin America. Methods Rainy seasons were defined for each study site using climatological information from the World Meteorological Organization. The dengue attack rate in the placebo group for each study month was calculated as the number of symptomatic, virologically-confirmed dengue events in a given month divided by the number of participants at risk in the same month. Time-dependent Cox proportional hazard models were used to test whether rainy season was associated with dengue disease and whether it modified vaccine efficacy in each of the two trials and in both of the trials combined. Findings Rainy season, country, and age were all significantly associated with dengue disease in both studies. Vaccine efficacy did not change during the rainy season in any of the analyses. Conclusions Although dengue transmission and exposure are expected to increase during the rainy season, our results indicate that CYD-TDV vaccine efficacy remains constant throughout the year in endemic regions. © 2018 Pasin et al.This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-85058416628&doi=10.1371%2fjournal.pone.0207878&partnerID=40&md5=50a51a0ad5e1a726e2ae7ee34d776027
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Vaccines, Attenuated
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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Pasin C.. "Periods of high dengue transmission defined by rainfall do not impact efficacy of dengue vaccine in regions of endemic disease". ไม่ระบุหน่วยงาน. ม.ป.ป.

Pasin C.. "Periods of high dengue transmission defined by rainfall do not impact efficacy of dengue vaccine in regions of endemic disease". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



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Periods of high dengue transmission defined by rainfall do not impact efficacy of dengue vaccine in regions of endemic disease
Pasin C.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
Double Dengue Serotypes in Asymptomatic Populations Living in An Area of Thailand Endemic for Dengue Hemorrhagic Fever Potent neutralizing human monoclonal antibodies preferentially target mature dengue virus particles: Implication for novel strategy for dengue vaccine Spatial variations in dengue transmission in schools in Thailand Emergence of genotype Cosmopolitan of dengue virus type 2 and genotype III of dengue virus type 3 in Thailand Dengue forecasting model using sarima model to predict the incidence of dengue in Thailand Accuracy of clinical diagnosis of dengue episodes in the RV144 HIV vaccine efficacy trial in Thailand Impact of glucose-6-phosphate dehydrogenase deficiency on dengue infection in Myanmar children Efficacy Evaluation of Deltamethrin and Cypermethrin Against Insecticide-resistant and -susceptible Strains of Dengue Vector Aedes aegypti Identification of changes in dendritic cell subsets that correlate with disease severity in dengue infection Relationships between dengue virus infection in mosquito vector, (Aedes aegypti), dengue cases and weather conditions in Samut Sakhon Province, Thailand
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